Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals

  • Jemmyson Romário de Jesus

Part of the Springer Theses book series (Springer Theses)

Table of contents

About this book


This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.


Depletion of Abundant Proteins Proteomic Profiling Immunoaffinity Techniques Metallomics Magnetic Nanoparticles (MNPs) Sample Preparation Human Blood Serum Psychatric Disease Bipolar Disorder Schizophrenia

Authors and affiliations

  • Jemmyson Romário de Jesus
    • 1
  1. 1.Institute of ChemistryUniversity of CampinasCampinasBrazil

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