Stem Cell-Based Therapy for Lung Disease

  • Janette K. Burgess
  • Irene H. Heijink

Table of contents

  1. Front Matter
    Pages i-viii
  2. Roderick de Hilster, Minghui Li, Wim Timens, Machteld Hylkema, Janette K. Burgess
    Pages 1-12
  3. Stem/Stromal Cells Populations in the Lung

  4. Preclinical Evidence and Clinical Applications in Chronic Lung Diseases

    1. Front Matter
      Pages 71-71
    2. Deniz A. Bölükbas, Iran Augusto Neves Da Silva, Kristina Rydell-Törmänen, Darcy E. Wagner
      Pages 73-96
    3. Sara Rolandsson Enes, Juan J. Uriarte, Robert A. Pouliot, Daniel J. Weiss
      Pages 97-118
    4. Vincent Yeung, Gareth R. Willis, Elizabeth Taglauer, S. Alex Mitsialis, Stella Kourembanas
      Pages 131-152
    5. Steven T. Leung, Timothy S. Leach, Anthony Atala, Sean V. Murphy
      Pages 179-198
    6. Emanuele Rezoagli, Emma J. Murphy, John Laffey, Daniel O’Toole
      Pages 219-238
  5. Stem Cell Delivery Systems and Devices

    1. Front Matter
      Pages 239-239
    2. Sally Yunsun Kim, Wojciech Chrzanowski
      Pages 241-253
  6. Conclusion

    1. Front Matter
      Pages 255-255

About this book


This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies.

Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung.

The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application.

This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.


regenerative medicine abnormal lung tissue repair lung cell regeneration extracellular matrix lung pathogenesis bio-active scaffolds mesenchimal stromal cells in the lung

Editors and affiliations

  • Janette K. Burgess
    • 1
  • Irene H. Heijink
    • 2
  1. 1.The University of GroningenUniversity Medical Center Groningen, Department of Pathology and Medical BiologyGroningenThe Netherlands
  2. 2.The University of GroningenUniversity Medical Center Groningen, Department of Pathology and Medical BiologyGroningenThe Netherlands

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