Biochemistry for Anesthesiologists and Intensivists

  • Fernando Alemanno

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Fernando Alemanno
    Pages 15-21
  3. Fernando Alemanno
    Pages 23-34
  4. Francesca Alemanno, Fernando Alemanno
    Pages 49-70
  5. Fernando Alemanno
    Pages 71-74
  6. Mario Bosco, Fernando Alemanno
    Pages 75-95
  7. Fernando Alemanno
    Pages 97-117
  8. Fernando Alemanno
    Pages 119-121
  9. Francesca Alemanno, Fernando Alemanno
    Pages 123-138
  10. Fernando Alemanno
    Pages 139-159
  11. Fernando Alemanno
    Pages 167-188
  12. Fernando Alemanno
    Pages 189-205
  13. Paolo Grossi, Fernando Alemanno
    Pages 207-223
  14. Fernando Alemanno
    Pages 225-237
  15. Fernando Alemanno
    Pages 239-247
  16. Fernando Alemanno
    Pages 249-250

About this book


This book discusses and explains the importance of biochemistry knowledge in understanding what happens to patients during anesthesia and/or to those being in intensive care. It covers a wide range of topics, such as Cerebral Edema, Shock, Blood-Brain Barrier, The Pulmonary surfactant, The Acid – Base equilibrium, Local anaesthetics, Perineural adjuvants, Normobaric Oxygen Therapy, Theories of Narcosis. Hyperventilation effects and consequences are also presented. For instance, by hyperventilating a patient with a PaCO2 significantly below 25 mmHg, we risk blocking pyruvic acid carboxylation and transforming it into oxalacetic acid, which in turn knocks out the Krebs cycle, possibly leading to a complication, i.e. to metabolic acidosis and not to compensation for respiratory alkalosis. It is also worth remembering that vitamins are actually molecules of pretty considerable potency and should not be simply intended as integrators. If we inject a patient under intensive care with vitamin C, this not only plays a capillary-protective role but facilitates the conversion of dopamine to noradrenaline. As far as vitamin B6 goes, not only is it the most natural of antiemetics but the coenzyme responsible for transforming glutamate as one of the most powerful excitatory mediators into GABA, one of the fiercest inhibitors. Anesthesiological and intensive care practice require a detailed biochemistry knowledge to avoid onset of complications and/or to deal with unexpected events promptly and appropriately.

The book is intended for anesthesiologists, intensivists, anesthesia teachers, anesthesia trainees and residents.


cerebral edema shock acid-base balance theories of narcosis local anesthetics

Editors and affiliations

  • Fernando Alemanno
    • 1
  1. 1.Anesthesia Resuscitation and Pain TherapyBrescia Nosocomial InstitutesBresciaItaly

Bibliographic information

Industry Sectors
Health & Hospitals