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Biomarkers of Human Aging

  • Alexey Moskalev
Book

Part of the Healthy Ageing and Longevity book series (HAL, volume 10)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Alexey Moskalev
    Pages 1-4
  3. Biomarkers of Aging and Health

    1. Front Matter
      Pages 5-5
    2. Boris Veytsman, Tiange Cui, Ancha Baranova
      Pages 7-21
    3. Timothy V. Pyrkov, Peter O. Fedichev
      Pages 23-36
    4. Jonathan Sholl, Suresh I. S. Rattan
      Pages 37-46
    5. Yizhen Yan, Yonglin Mu, Weiyang Chen, Jing-Dong J. Han
      Pages 47-66
    6. I. A. Solovev, M. V. Shaposhnikov, Alexey Moskalev
      Pages 67-78
  4. Proteomics and Glycomics Biomarkers of Aging

    1. Front Matter
      Pages 79-79
    2. M. Vilaj, I. Gudelj, I. Trbojević-Akmačić, G. Lauc, M. Pezer
      Pages 81-99
    3. Bertrand Friguet, Martin A. Baraibar
      Pages 101-120
    4. Jacek M. Witkowski, Ewa Bryl, Tamas Fulop
      Pages 121-134
  5. Genetics and Epigenetics Aging Markers

    1. Front Matter
      Pages 135-135
    2. Paola Sebastiani, Anastasia Gurinovich, Harold Bae, Thomas T. Perls
      Pages 137-153
    3. Morgan E. Levine
      Pages 155-171
    4. Dmitriy I. Podolskiy, Vadim N. Gladyshev
      Pages 173-183
    5. Anna Kovalchuk, Bryan Kolb, Olga Kovalchuk
      Pages 185-202
    6. Alexej Abyzov, Flora M. Vaccarino, Alexander E. Urban, Vivekananda Sarangi
      Pages 203-228
  6. Immunosenescence and Inflammaging Markers

    1. Front Matter
      Pages 229-229
    2. Tamas Fulop, Alan Cohen, Glenn Wong, Jacek M. Witkowski, Anis Larbi
      Pages 231-251
    3. Daria A. Kashtanova, Olga N. Tkacheva, Irina D. Strazhesko, Ekaterina N. Dudinskaya, Yu V. Kotovskaya, A. S. Popenko et al.
      Pages 263-278
  7. Systems Biology of Aging, Biological Age and Mortality Markers

    1. Front Matter
      Pages 279-279
    2. Polina Mamoshina, Alex Zhavoronkov
      Pages 281-291
    3. James H. Cole, Katja Franke, Nicolas Cherbuin
      Pages 293-328
    4. Irina D. Strazhesko, Daria A. Kashtanova, Ekaterina N. Dudinskaya, Olga N. Tkacheva
      Pages 329-348
    5. Hongxia Zhang, Brian Wang, Kunlin Jin
      Pages 349-371
    6. Arnold Mitnitski, Kenneth Rockwood
      Pages 399-415
  8. Back Matter
    Pages 417-421

About this book

Introduction

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging.

In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function).

The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education.

Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging.

Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

 


Keywords

Aging Biomarker Genome Epigenome Immunosenescence

Editors and affiliations

  • Alexey Moskalev
    • 1
  1. 1.Laboratory of Geroprotective and Radioprotective TechnologiesInstitute of Biology, Komi Science Center of RASSyktyvkarRussia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-24970-0
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-24969-4
  • Online ISBN 978-3-030-24970-0
  • Series Print ISSN 2199-9007
  • Series Online ISSN 2199-9015
  • Buy this book on publisher's site
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Health & Hospitals
Biotechnology