Early Life Origins of Ageing and Longevity

  • Alexander Vaiserman

Part of the Healthy Ageing and Longevity book series (HAL, volume 9)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Daniel J. Hoffman, Alessandro Bigoni, Adriana Carrieri
      Pages 3-22
  3. Experimental Study of DOHaD

    1. Front Matter
      Pages 35-35
    2. Thea N. Golden, Rebecca A. Simmons
      Pages 57-66
    3. Simon C. Langley-Evans, Beverly Muhlhausler
      Pages 87-120
    4. Barbara Barth, André K. Portella, Laurette Dubé, Michael J. Meaney, Patricia Pelufo Silveira
      Pages 121-140
    5. Clare Shere, Cyrus Cooper, Elaine M. Dennison
      Pages 141-165
    6. Elisabetta Damiani, Rosita Gabbianelli
      Pages 167-187
  4. Epidemiological Evidence

    1. Front Matter
      Pages 189-189
    2. Susanne R. de Rooij
      Pages 191-208
    3. Emma C. Johns, David Q. Stoye, Liu Yang, Rebecca M. Reynolds
      Pages 209-231
    4. Tessa J. Roseboom
      Pages 233-244
    5. Alexander Vaiserman, Oleh Lushchak
      Pages 269-282
  5. Perspectives and Implications

    1. Front Matter
      Pages 283-283
    2. M. Lelinneth B. Novilla, Michael C. Goates, Michael D. Barnes, Justin M. Packer
      Pages 285-302
  6. Back Matter
    Pages 303-310

About this book


This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life.

While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process.

Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life.

In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns.

Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.


Developmental programming Aging Age-related disease Longevity Epigenetics

Editors and affiliations

  • Alexander Vaiserman
    • 1
  1. 1.Laboratory of EpigeneticsInstitute of GerontologyKievUkraine

Bibliographic information