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Current Immunotherapeutic Strategies in Cancer

  • Matthias Theobald

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 214)

Table of contents

  1. Front Matter
    Pages i-v
  2. Sagun Parakh, Dylan King, Hui K. Gan, Andrew M. Scott
    Pages 1-70
  3. Astrid Holzinger, Hinrich Abken
    Pages 93-128
  4. Thomas W. Smith Jr., Michael I. Nishimura
    Pages 129-151
  5. Mathias Vormehr, Mustafa Diken, Özlem Türeci, Ugur Sahin, Sebastian Kreiter
    Pages 153-167
  6. Annette Paschen, Dirk Schadendorf
    Pages 169-187

About this book

Introduction

This book offers a comprehensive review of recent advances in cancer immunotherapy, and explores the value and limitations of the most effective current therapeutic strategies and emerging treatment modalities. It discusses in detail the successes achieved using monoclonal antibodies (mAbs), including developments with regard to conjugated mAbs and also bispecific mAbs as novel treatment options for leukemia and solid tumors. It also examines the advances toward personalized immunotherapy, focusing on the effectiveness of adoptive cell therapy using genetically engineered T cells with tumor-associated antigen-specific T-cell receptors and chimeric antigen receptors, as well as the role of tailored vaccines based on the patient’s cancer mutanome. Further, it describes the impressive therapeutic results recently achieved with checkpoint inhibitors, and analyzes novel strategies to modulate the immunosuppressive tumor microenvironment. Written by leading international experts and providing up-to-date information on emerging strategies, such as oncolytic virus-based therapy, epigenetic therapy, and combination therapy, the book appeals to all those with an interest in immunotherapy as it comes of age.

Keywords

1. Cancer Immunotherapy 2. Vaccines 3. Adoptive Cell Transfer 4. Checkpoint Inhibitors 5. Monoclonal Antibodies 6. Tumor Microenvironment

Editors and affiliations

  • Matthias Theobald
    • 1
  1. 1.Department of Hematology, Oncology and Pneumology, University Cancer Center (UCT) MainzJohannes Gutenberg University Medical CenterMainzGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-23765-3
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-030-23764-6
  • Online ISBN 978-3-030-23765-3
  • Series Print ISSN 0080-0015
  • Series Online ISSN 2197-6767
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology
Oncology & Hematology