© 2019

Pot, Atom, and Step Economy (PASE) Synthesis


Part of the SpringerBriefs in Molecular Science book series (BRIEFSMOLECULAR)

Also part of the SpringerBriefs in Green Chemistry for Sustainability book sub series (GREENCHEMIST)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Wei Zhang, Wen-Bin Yi
    Pages 1-4
  3. Wei Zhang, Wen-Bin Yi
    Pages 5-13
  4. Wei Zhang, Wen-Bin Yi
    Pages 15-26
  5. Wei Zhang, Wen-Bin Yi
    Pages 27-40
  6. Wei Zhang, Wen-Bin Yi
    Pages 41-47
  7. Wei Zhang, Wen-Bin Yi
    Pages 49-49

About this book


This book emphasizes the atom economy aspect of multicomponent reactions. It describes how this methodology has been applied to several named reactions. Among the “twelve principles of green chemistry”, atom economy addresses ‘synthetic efficiency’. A multicomponent reaction can be defined as an energy, cost, and time efficient method for organic synthesis. Instead of making one or two bonds in a chemical transformation, multicomponent reactions generate several chemical bonds in a single operation. This book presents a series of detailed reaction mechanisms that beautifully illustrate this principle. Multicomponent reactions are widely applied to the preparation of complex and diverse molecular structures in academic and industrial research laboratories. As such, this book is targeted at researchers involved in green organic chemistry.


Atom Economy Examples Atom Economy in Green Chemistry Atom Efficiency Efficient Synthesis Green Organic Chemistry Multicomponent Reactions One-pot Synthesis

Authors and affiliations

  1. 1.Chemistry DepartmentUniversity of Massachusetts BostonBostonUSA
  2. 2.School of Chemical EngineeringNanjing University of Science and TechnologyNanjingChina

About the authors

Wei Zhang, Ph.D.
Associate Professor
Department of Chemistry
University of Massachusetts Boston
Research areas: fluorous technology, medicinal chemistry, chemical library synthesis, free radical chemistry, and green chemistry
The 3rd most published author in fluorous chemistry (after D. P. Curran and J. A. Gladysz)
Over 140 publications including 3 Chemical Reviews and 3 Tetrahedron Reports articles
Over 2,900 citations (H-Index 30), the top 1% of the cited authors for journals in the Life Sciences.

Bibliographic information

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