Hepatocellular Carcinoma

Translational Precision Medicine Approaches

  • Yujin Hoshida

Part of the Molecular and Translational Medicine book series (MOLEMED)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Clinical Demographics and Management

    1. Front Matter
      Pages 1-1
    2. Naoto Fujiwara, Po-Hong Liu, Sai Krishna Athuluri-Divakar, Shijia Zhu, Yujin Hoshida
      Pages 3-25
    3. Amit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai
      Pages 27-51
    4. Yueran Zhuo, Qiushi Chen, Jagpreet Chhatwal
      Pages 53-67
  3. Diagnosis and Prognostication

    1. Front Matter
      Pages 69-69
    2. Naik Vietti Violi, Sara Lewis, Stefanie Hectors, Daniela Said, Bachir Taouli
      Pages 71-92
    3. Connor A. West, Alyson P. Black, Anand S. Mehta
      Pages 93-107
    4. Irun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting
      Pages 125-141
  4. Treatment

    1. Front Matter
      Pages 143-143
    2. Caitlin A. Hester, Adam C. Yopp
      Pages 145-167
    3. Patrick D. Sutphin, Daniel Lamus, Sanjeeva P. Kalva, Junjie Li, Ian R. Corbin
      Pages 169-194
    4. Amit Mahipal, Anuhya Kommalapati, Rutika Mehta, Richard D. Kim
      Pages 225-238
    5. Zachary J. Brown, Tim F. Greten
      Pages 239-253
    6. Derek J. Erstad, Allen A. Razavi, Shen Li, Kenneth K. Tanabe, Bryan C. Fuchs
      Pages 255-289
  5. Molecular Pathogenesis and Therapeutic Discovery

    1. Front Matter
      Pages 291-291
    2. Antonio Saviano, Natascha Roehlen, Alessia Virzì, Armando Andres Roca Suarez, Yujin Hoshida, Joachim Lupberger et al.
      Pages 317-331
    3. Pedro Molina-Sánchez, Amaia Lujambio
      Pages 333-358
  6. Yujin Hoshida
    Pages C1-C1
  7. Back Matter
    Pages 359-364

About this book


This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields.

By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.


prognostic staging Liquid biopsy Chemoprevention hepatocarcinogenesis Molecular pathogenesis

Editors and affiliations

  • Yujin Hoshida
    • 1
  1. 1.Department of Internal MedicineUniversity of Texas Southwestern Medical CenterDallasUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Humana, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-21539-2
  • Online ISBN 978-3-030-21540-8
  • Series Print ISSN 2197-7852
  • Series Online ISSN 2197-7860
  • Buy this book on publisher's site
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