Current Applications for Overcoming Resistance to Targeted Therapies

  • Myron R. Szewczuk
  • Bessi Qorri
  • Manpreet Sambi

Part of the Resistance to Targeted Anti-Cancer Therapeutics book series (RTACT, volume 20)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Manpreet Sambi, Myron R. Szewczuk
    Pages 1-33
  3. Jessica Swanner, W. Hans Meisen, Ryan M. McCormack, Cole T. Lewis, Bangxing Hong, Balveen Kaur
    Pages 63-96
  4. Xianda Zhao, Ce Yuan, John Markus Rieth, Dechen Wangmo, Subbaya Subramanian
    Pages 97-129
  5. Noura Al-Zeheimi, Sirin A. Adham
    Pages 131-159
  6. Somaira Nowsheen, Fen Xia
    Pages 161-189
  7. Andreia V. Pinho, Jenny H. Lee, Helen Rizos
    Pages 223-258
  8. Matt McTaggart, Cecile Malardier-Jugroot
    Pages 291-312
  9. Back Matter
    Pages 313-320

About this book


Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.


chemoresistance drug development pancreatic cancer breast cancer colorectal cancer prostate cancer pathophysiology of aggressive cancers

Editors and affiliations

  • Myron R. Szewczuk
    • 1
  • Bessi Qorri
    • 2
  • Manpreet Sambi
    • 3
  1. 1.Department of Biomedical and Molecular SciencesQueen’s UniversityKingstonCanada
  2. 2.Department of Biomedical and Molecular SciencesQueen’s UniversityKingstonCanada
  3. 3.Department of Biomedical and Molecular SciencesQueen’s UniversityKingstonCanada

Bibliographic information

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