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Calcitonin Gene-Related Peptide (CGRP) Mechanisms

Focus on Migraine

  • Susan D. Brain
  • Pierangelo Geppetti

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 255)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Kate Arkless, Fulye Argunhan, Susan D. Brain
    Pages 1-12
  3. John Simms, Sarah Routledge, Romez Uddin, David Poyner
    Pages 23-36
  4. Graeme S. Cottrell
    Pages 37-64
  5. Francesco De Logu, Romina Nassini, Lorenzo Landini, Pierangelo Geppetti
    Pages 65-84
  6. Anne-Sophie Wattiez, Mengya Wang, Andrew F. Russo
    Pages 85-107
  7. Håkan Ashina, Henrik Winther Schytz, Messoud Ashina
    Pages 109-120
  8. Lars Edvinsson
    Pages 121-130
  9. Eloísa Rubio-Beltrán, Antoinette Maassen van den Brink
    Pages 131-140
  10. David A. Walsh, Daniel F. McWilliams
    Pages 141-167
  11. Roxana-Maria Rujan, Christopher A. Reynolds
    Pages 169-192

About this book

Introduction

This book is designed to focus on the role of Calcitonin Gene-Related Peptide (CGRP) in health and disease. This peptide, originally discovered in the 1980s as a sensory neuropeptide with cardiovascular effects, is now known to play a distinct role in the pain processing of migraine.  The various chapters address the origin, localization and function of CGRP and its receptor in the peripheral nervous system, in the cardiovascular system, and in other tissues and organs. Further attention is paid to the drug discovery pathway where recent findings show the beneficial effect of small molecule antagonists of the CGRP receptors for the relief of the migraine attack and of monoclonal antibodies against CGRP or the CGRP receptor for migraine prevention. 

Keywords

calcitonin gene-related peptide neurogenic inflammation vascular innervation migraine cluster headache

Editors and affiliations

  • Susan D. Brain
    • 1
  • Pierangelo Geppetti
    • 2
  1. 1.School of Cardiovascular Medicine & SciencesKing’s College LondonLondonUK
  2. 2.Department of Health SciencesUniversity of FlorenceFlorenceItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-21454-8
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-21453-1
  • Online ISBN 978-3-030-21454-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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