Bioactive Ceramides in Health and Disease

Intertwined Roles of Enigmatic Lipids

  • Johnny Stiban

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1159)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Johnny Stiban
    Pages 1-3
  3. Emilia Rappocciolo, Johnny Stiban
    Pages 5-31
  4. Marco Colombini
    Pages 33-48
  5. Iris D. Zelnik, Batsheva Rozman, Eden Rosenfeld-Gur, Shifra Ben-Dor, Anthony H. Futerman
    Pages 49-63
  6. Melissa L. Berwick, Brittany A. Dudley, Kenneth Maus, Charles E. Chalfant
    Pages 65-77
  7. Ana E. Ventura, Beatriz Mestre, Liana C. Silva
    Pages 79-108
  8. Faris Matanes, Waleed O. Twal, Samar M. Hammad
    Pages 109-138
  9. Richard Grambergs, Koushik Mondal, Nawajes Mandal
    Pages 139-152
  10. Back Matter
    Pages 153-153

About this book


This book is about the various roles of bioactive ceramides and other sphingolipids in cellular biology. The enigmatic biophysical and biochemical properties of ceramides and their propensity to influence membranes whether as rafts or protein-permeable channels are heavily discussed. Metabolism of ceramides and their metabolites is also focused with ceramide synthase family of proteins being a target of extensive review. Ceramide 1-phosphate and other sphingolipids are also presented in cellular physiology and pathophysiology. Prokaryotic origins of mitochondria at the level of membranes and the occurrence of apoptosis in bacteria are presented.

Many aspects of ceramide and sphingolipid biology are addressed in this book. Its focus is the metabolism of ceramide in normal and diseased states and the biophysical and biochemical mechanisms governing the bioactivity of these molecules. Sphingolipid research has surged over the past thirty years and this book gathers the recent findings of various aspects of sphingolipid biochemistry.

World-renowned scientists from the field of lipid biology, specifically sphingolipid biochemistry, were gathered to write this book. Scholars from most continents of the globe committed to write diligently about their expertise and the newest findings in the relevant fields. This book came to fruition after almost a year and a half of laborious preparation and diligent writings.

This book is targeted to the experienced reader who is looking to read about the various aspects of bioactive ceramide signaling, as well as to the newcomer into the field, as the topics are explained in concise yet very informative manner. The authors and editor wish all readers a pleasant time reading this volume, and are adamant that this book will meet all expectations.



ceramide lipids apoptosis mitochondria cancer obesity

Editors and affiliations

  • Johnny Stiban
    • 1
  1. 1.Department of Biology and Biochemistry, Faculty of ScienceBirzeit UniversityRamallahPalestine, State of

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