Difficult To Treat Asthma

Clinical Essentials

  • Sandhya Khurana
  • Fernando Holguin

Part of the Respiratory Medicine book series (RM)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Steve N. Georas, F. Eun-Hyung Lee, Merin Kuruvilla
    Pages 1-23
  3. Marc C. Gauthier, Merritt L. Fajt
    Pages 25-38
  4. Maria Duenas, Juan P. Wisnivesky, Alex Federman
    Pages 39-53
  5. Jason Kwah, Anju Peters, Sumita Khatri
    Pages 55-74
  6. Ambrose Lau, Susan M. Tarlo
    Pages 75-89
  7. Aaron B. Holley, Linda Rogers
    Pages 91-106
  8. Theo J. Moraes, Wendy C. Moore, Padmaja Subbarao
    Pages 107-122
  9. Arjun Mohan, Jon Grace, Anne Mainardi, Geoffrey Chupp, Njira Lugogo
    Pages 123-153
  10. Nicola A. Hanania, Jessica Stern, R. John Looney
    Pages 155-180
  11. Anurag Bhalla, Parameswaran Nair
    Pages 181-206
  12. Meghan Althoff, Fernando Holguin
    Pages 207-227
  13. Jennifer A. Namazy, Michael Schatz, Augusto A. Litonjua
    Pages 243-264
  14. Deepa Rastogi, Andrew H. Liu
    Pages 265-295
  15. Navitha Ramesh, Fernando Holguin, Sandhya Khurana
    Pages 297-311
  16. Shu-Yi Liao, Amir A. Zeki, Nizar Jarjour
    Pages 313-324
  17. Back Matter
    Pages 325-334

About this book


This book provides a practical, stepwise, evidence-based approach to effective management of patients with difficult to treat asthma. The impact of asthma on morbidity and healthcare utilization increases exponentially with severity. Severe refractory asthma accounts for less than 5% of all asthma. Its prevalence, however, is often overestimated as there are several other confounding factors that make asthma ‘difficult to treat’. Many novel (albeit expensive) therapies are now available and providers caring for patients with severe asthma are charged with selecting the best evidence treatment. This calls for complex and nuanced decision-making. Whether people with asthma gain and maintain control over their condition depends not only on the availability of effective drugs, but also multiple patient and healthcare provider behaviors. Therefore, now more than ever, it has become increasingly important to differentiate “difficult” from “severe refractory” asthma to allow identification of patients most likely to benefit from these therapies. 
This volume delves into the current understanding of mechanisms and increasingly recognized heterogeneity of this complex disease. It discusses a structured approach to identification and optimization of factors contributing to poor asthma control, including nonadherence, comorbidities and occupational/environmental triggers. The book includes ‘state of the art’ reviews on recent advances in traditional and targeted asthma therapies, as well as a glimpse into what the future may hold. Highlights include a comprehensive guide to management of severe asthma in children and pregnancy, as well as practical considerations to management of asthma based on different clinical phenotypes. Each chapter is authored by leading experts in the field who share their own clinical approach.  This is an ideal guide for clinical pulmonologists and allergist/immunologists, as well as primary care providers, physician extenders in specialty practice, physicians in pulmonary/allergy training, and even industry partners.  


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Editors and affiliations

  • Sandhya Khurana
    • 1
  • Fernando Holguin
    • 2
  1. 1.Mary Parkes Center for Asthma, Allergy & Pulmonary Care, University of Rochester School of MedicineRochesterUSA
  2. 2.Asthma Clinical & Research Programs Pulmonary Sciences and Critical CareUniversity of ColoradoDenverUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Humana, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-20811-0
  • Online ISBN 978-3-030-20812-7
  • Series Print ISSN 2197-7372
  • Series Online ISSN 2197-7380
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology