An Example of Positive Biology

  • Calogero Caruso

Table of contents

  1. Front Matter
    Pages i-vii
  2. Giulia Accardi, Anna Aiello, Sonya Vasto, Calogero Caruso
    Pages 1-21
  3. Giulia Accardi, Mattia Emanuela Ligotti, Giuseppina Candore
    Pages 23-34
  4. Anna Aiello, Mattia Emanuela Ligotti, Andrea Cossarizza
    Pages 35-51
  5. Luca Falzone, Massimo Libra, Jerry Polesel
    Pages 71-86
  6. Francesco Villa, Anna Ferrario, Annibale Alessandro Puca
    Pages 87-97
  7. Dina Bellizzi, Francesco Guarasci, Francesca Iannone, Giuseppe Passarino, Giuseppina Rose
    Pages 99-133
  8. Lu Wu, Angelo Zinellu, Luciano Milanesi, Salvatore Rubino, David J. Kelvin, Ciriaco Carru
    Pages 149-160
  9. Antonia Trichopoulou, Vassiliki Benetou
    Pages 161-168
  10. Sergio Davinelli, Giovanni Scapagnini
    Pages 169-179

About this book


This state-of-the-art review on longevity focuses on centenarians, studied as a model of positive biology.

The extraordinary rise in the elderly population in developed countries underscores the importance of studies on ageing and longevity in order to decrease the medical, economic and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies.

Centenarians have reached the extreme limits of human life span. Those in relatively good health, who are able to perform their routine daily tasks, are the best examples of extreme longevity, representing selected individuals in which the appearance of major age-related diseases – including cancer and cardiovascular diseases – has been consistently delayed or avoided. 

The relationship between causality and chance is an open discussion topic in many disciplines. In particular, ageing, the related diseases, and longevity are difficult to define as a consequence of causality, chance or both. Discussing the relevance of these different factors in the attainment of longevity, the book gathers contributions on genetic, epigenetic and phenotypic aspects of centenarians.

The “positive biology” approach is applied to clarify the causes of positive phenotypes, as well as to explain the biological mechanisms of health and well-being with the aim of preventing and/or reducing frailty and disability in the elderly.


Aging Longevity Phenotype Genetics Epigenetics

Editors and affiliations

  • Calogero Caruso
    • 1
  1. 1.Department of Biomedicine, Neurosciences and Advanced DiagnosticsUniversity of PalermoPalermoItaly

Bibliographic information

Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology