© 2019

Thrombosis and Hemostasis in Cancer

  • Gerald Soff
  • Explores the current understanding of thrombosis and hemostasis in cancer

  • Examines how cancers activate the coagulation system and how an activated coagulation system leads to more aggressive cancer growth

  • Addresses a wide range of treatment-related issues


Part of the Cancer Treatment and Research book series (CTAR, volume 179)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Anna Falanga, Francesca Schieppati, Laura Russo
    Pages 11-36
  3. Aime T. Franco, Jerry Ware
    Pages 37-54
  4. Anjlee Mahajan, Ted Wun
    Pages 69-85
  5. M. D. Debbie Jiang, M. D. Alfred Ian Lee
    Pages 87-101
  6. Jodi V. Mones, Gerald Soff
    Pages 139-150
  7. Mari R. Thomas, Marie Scully
    Pages 151-158
  8. Kamya Sankar, Brady L. Stein, Raajit K. Rampal
    Pages 159-178
  9. Charlene Mantia, Jeffrey I. Zwicker
    Pages 179-189
  10. Simon Mantha
    Pages 191-203

About this book


In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer.   

It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike. 


Thrombosis Hemostasis Pathophysiology Thrombotic Risk Thrombocytopenia Microangiopathy in Cancer Myeloproliferative Diseases Hemorrhage in the Cancer Patient Tumor Thrombus Thrombocytopenia in Cancer

Editors and affiliations

  • Gerald Soff
    • 1
  1. 1.Medicine/HematologyMemorial Sloan Kettering Cancer CenterNew YorkUSA

About the editors

Gerald A Soff MD is the Chief of the Hematology Service and co-Director of the Hematology/Oncology Fellowship program at Memorial Sloan Kettering Cancer Center. He previously was the Chief of the Hematology/Oncology Division at SUNY Downstate Medical Center (2006-2008), and had been on the faculty of the Feinberg School of Medicine - Northwestern University (1991-2005). Dr. Soff’s clinical practice is focused on the hematologic complications of cancer and cancer therapy, particularly thrombosis, thrombocytopenia, and other coagulation disorders. His basic science research has included studies of vascular cells, angiogenesis, and angiogenesis inhibition. He is a clinical research leader in the study and validation of the use of direct oral anticoagulants for treatment and prophylaxis of cancer associated thrombosis. Dr. Soff has published over 70 original research papers, as well as numerous invited review articles and book chapters. Since 2014, Dr. Soff has been a member of the National Comprehensive Cancer Network Cancer-Associated Venous Thromboembolic Disease panel. Previously, from 2011 to 2014, he had been on the NCCN Cancer and Chemotherapy-Induced Anemia Panel. He is a member of the American Society of Hematology Committee on Training and served as the Medical Education Subcommittee Chair from 2013-2018. He has mentored and continues to mentor numerous students, residents, fellows, and junior faculty, to facilitate their career development.

Bibliographic information

  • Book Title Thrombosis and Hemostasis in Cancer
  • Editors Gerald Soff
  • Series Title Cancer Treatment and Research
  • Series Abbreviated Title Cancer Treatment,Research
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-030-20314-6
  • Softcover ISBN 978-3-030-20317-7
  • eBook ISBN 978-3-030-20315-3
  • Series ISSN 0927-3042
  • Series E-ISSN 2509-8497
  • Edition Number 1
  • Number of Pages XIV, 203
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
    Cancer Research
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology