Breast Cancer Metastasis and Drug Resistance

Challenges and Progress

  • Aamir Ahmad

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1152)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Steven S. Coughlin
    Pages 9-29
  3. Clement G. Yedjou, Jennifer N. Sims, Lucio Miele, Felicite Noubissi, Leroy Lowe, Duber D. Fonseca et al.
    Pages 31-49
  4. Mirna Azalea Romero, Oznur Bayraktar Ekmekcigil, Bakiye Goker Bagca, Cigir Biray Avci, Uteuliyev Yerzhan Sabitaliyevich, Tokmurziyeva Gulnara Zhenisovna et al.
    Pages 65-73
  5. Lauren Kalinowski, Jodi M. Saunus, Amy E. McCart Reed, Sunil R. Lakhani
    Pages 75-104
  6. Rie K. Tahara, Takae M. Brewer, Richard L. Theriault, Naoto T. Ueno
    Pages 105-129
  7. Manpreet Sambi, Bessi Qorri, William Harless, Myron R. Szewczuk
    Pages 131-172
  8. Derek W. Edwardson, Amadeo M. Parissenti, A. Thomas Kovala
    Pages 173-215
  9. Mohd Farhan, Mohammad Aatif, Prasad Dandawate, Aamir Ahmad
    Pages 229-241
  10. Ning Yin, Liu Yi, Sumbul Khalid, Ulku Ozbey, Uteuliev Yerzhan Sabitaliyevich, Ammad Ahmad Farooqi
    Pages 243-252
  11. Sobia Tabassum, Rashda Abbasi, Nafees Ahmad, Ammad Ahmad Farooqi
    Pages 271-281
  12. Ghazala Butt, Durray Shahwar, Muhammad Zahid Qureshi, Rukset Attar, Misbah Akram, Yelda Birinci et al.
    Pages 283-292
  13. Samriddhi Shukla, Dhanamjai Penta, Priya Mondal, Syed Musthapa Meeran
    Pages 293-310
  14. Nataly Naser Al Deen, Farah Nassar, Rihab Nasr, Rabih Talhouk
    Pages 335-364
  15. Ghazala Butt, Ilhan Yaylim, Rukset Attar, Aliye Aras, Mirna Azalea Romero, Muhammad Zahid Qureshi et al.
    Pages 365-375
  16. Tomas G. Lyons, Tiffany A. Traina
    Pages 377-399
  17. Kingsley O. Osuala, Kyungmin Ji, Raymond R. Mattingly, Bonnie F. Sloane
    Pages 401-411
  18. Sophie Roberts, Sally Peyman, Valerie Speirs
    Pages 413-427

About this book


Resistance to therapies, both targeted and systemic, and metastases to distant organs are the underlying causes of breast cancer-associated mortality. The second edition of Breast Cancer Metastasis and Drug Resistance brings together some of the leading experts to comprehensively understand breast cancer: the factors that make it lethal, and current research and clinical progress. This volume covers the following core topics: basic understanding of breast cancer (statistics, epidemiology, racial disparity and heterogeneity), metastasis and drug resistance (bone metastasis, trastuzumab resistance, tamoxifen resistance and novel therapeutic targets, including non-coding RNAs, inflammatory cytokines, cancer stem cells, ubiquitin ligases, tumor microenvironment and signaling pathways such as TRAIL, JAK-STAT and mTOR) and recent developments in the field (epigenetic regulation, microRNAs-mediated regulation, novel therapies and the clinically relevant 3D models). Experts also discuss the advances in laboratory research along with their translational and clinical implications with an overarching goal to improve the diagnosis and prognosis, particularly that of breast cancer patients with advanced disease.


bone metastasis breast cancer statistics breast cancer stem cells tamoxifen triple negative breast cancer

Editors and affiliations

  • Aamir Ahmad
    • 1
  1. 1.Mitchell Cancer InstituteUniversity of South AlabamaMobileUSA

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