Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy

A Comprehensive Guide

  • Daniel M. Trifiletti
  • Samuel T. Chao
  • Arjun Sahgal
  • Jason P. Sheehan

Table of contents

  1. Front Matter
    Pages i-xix
  2. Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy

    1. Front Matter
      Pages 1-1
    2. Golnaz Farhat, Deepa Sharma, Gregory J. Czarnota
      Pages 3-13
    3. Talicia Savage, Chandan Guha
      Pages 15-29
    4. Jarred Tanksley, Joseph K. Salama, John P. Kirkpatrick
      Pages 31-40
  3. Intracranial Radiosurgery Technique

    1. Front Matter
      Pages 41-41
    2. Yongsook C. Lee, Steven J. Goetsch, David J. Schlesinger, Stanley H. Benedict
      Pages 43-54
    3. Diogo P. Cordeiro, David J. Schlesinger
      Pages 55-65
    4. Erqi Pollom, Lei Wang, Iris C. Gibbs, Scott G. Soltys
      Pages 67-76
    5. William A. Friedman, Frank J. Bova
      Pages 77-82
    6. Giuseppe Minniti, Claudia Scaringi
      Pages 83-90
    7. Arpit M. Chhabra, Mudit Chowdhary, Minesh P. Mehta
      Pages 91-101
  4. Intracranial Radiosurgery by Indication

    1. Front Matter
      Pages 103-103
    2. Clayton Alonso, Jason P. Sheehan, Daniel M. Trifiletti
      Pages 105-111
    3. Cheng-chia Lee, Daniel M. Trifiletti, Jason P. Sheehan
      Pages 113-121
    4. David R. Raleigh, Penny K. Sneed
      Pages 123-129
    5. Jacqueline J. Tao, Justin Moore, Geoffrey Appelboom, Steven D. Chang
      Pages 131-140
    6. Srinivas Chivukula, Nicholas Au Yong, Matiar Jafari, Nader Pouratian
      Pages 141-150
    7. Fabio Frisoli, Jugal Shah, Travis C. Hill, Douglas Kondziolka
      Pages 151-161
    8. Ajay Niranjan, L. Dade Lunsford
      Pages 163-171
  5. Stereotactic Body Radiation Therapy Technique

    1. Front Matter
      Pages 173-173
    2. Young Lee, Arman Sarfehnia, Mark Ruschin
      Pages 175-183
    3. Jana Heitmann, Matthias Guckenberger
      Pages 185-193
    4. Benjamin J. Cooper, Yi Rong, Paul J. Keall
      Pages 195-215
    5. Arpit M. Chhabra, Melissa A. Frick, Tejan Diwanji, Jason K. Molitoris, Charles B. Simone II
      Pages 217-233
  6. Stereotactic Body Radiation Therapy by Indication

    1. Front Matter
      Pages 235-235
    2. William A. Stokes, Tyler P. Robin, Sameer K. Nath, Chad G. Rusthoven
      Pages 247-264
    3. Salman Faruqi, Chia-Lin Tseng, Jeremie Stephane Larouche, Leodante da Costa, Victor Yang, Giuseppina Laura Masucci et al.
      Pages 265-276
    4. Pablo Munoz-Schuffenegger, Aisling S. Barry, Laura A. Dawson
      Pages 277-288
    5. Michael R. Folkert, Raquibul Hannan, Neil B. Desai, Robert D. Timmerman
      Pages 289-305
    6. Osama Mohamad, Robert D. Timmerman, Raquibul Hannan
      Pages 307-317
    7. Pencilla Lang, Ian Poon, Lee Chin, Irene Karam
      Pages 319-329
    8. Aditya Juloori, Erin S. Murphy
      Pages 331-343
  7. The Future of Radiosurgery and SBRT

    1. Front Matter
      Pages 345-345
    2. Christopher Wilke, L. Chinsoo Cho, Paul W. Sperduto
      Pages 347-357
    3. Samuel T. Chao, Erin S. Murphy, Simon S. Lo, John H. Suh
      Pages 359-372
    4. Daniel N. Cagney, Tracy A. Balboni
      Pages 373-379
    5. Arrvind Raghunath, Vyshak Alva Venur, Manmeet S. Ahluwalia
      Pages 381-388
    6. Joseph H. Donahue, Juliana Bueno, Jason N. Itri
      Pages 389-413
    7. Sanjay Aneja, Rahul J. Kumar, James B. Yu
      Pages 415-424
  8. Back Matter
    Pages 425-435

About this book


This book is a comprehensive review of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT): its physics, clinical evidence, indications, and future directions. The utilization of stereotactic radiosurgery (SRS) and stereotactic body radiation therapy (SBRT) is increasing internationally because of several factors. First, it offers patients a local treatment option that has demonstrated effectiveness similar to traditional surgery without the morbidity of general anesthesia and open surgical resection. Second, recent advancements in the quality of scientific evidence supporting a SRS or SBRT-containing approach in patients continues to evolve and demonstrate favorable disease-specific outcomes with little, if any, toxicity in various anatomic disease sites and for various conditions including cancer, benign tumors, and other psychiatric and neurologic conditions. Third, and most provocatively, is the notion that definitive local therapy (i.e. SRS or SBRT) in patients with cancer can boost the immune system to fight cancer in other sites throughout the body. While traditional medical knowledge would suggest that all patients with metastatic cancer are incurable, there is a mounting body of evidence that there is a subset of these patients that can be cured with definitive SRS or SBRT. This volume thus delves into each of these benefits and aspects of treatment, guiding physicians to the best treatment plan for their patients.

Expert, international authors provide guidelines for SRS and SBRT use by clinicians. Chapters are divided into six main sections: Radiobiology of Radiosurgery and Stereotactic Body Radiation Therapy, Intracranial  Radiosurgery Technique, Intracranial Radiosurgery by Indication, Stereotactic Body Radiation Therapy Technique, Stereotactic Body Radiation Therapy by Indication, The Future of Radiosurgery and SBRT. Overall physics are explained, as well as specific considerations for particular surgical tools (including the Leksell Gamma Knife and Accuray CyberKnife), techniques (including fractionated and charged particle radiosurgery), and anatomic sites (including brain metastases, pituitary tumors, and the prostate). Detailed images and charts enhance the chapters. This book provides physicians with a single, practical resource incorporating both of these broad categories of treatment, SRS and SBRT, and better defines the current role and the direction of radiosurgery.


stereotactic radiosurgery steretactic body radiation therapy SRS SBRT tumors radiation oncology radiobiology

Editors and affiliations

  • Daniel M. Trifiletti
    • 1
  • Samuel T. Chao
    • 2
  • Arjun Sahgal
    • 3
  • Jason P. Sheehan
    • 4
  1. 1.Mayo Clinic, Radiation OncologyMayo Clinic School of Medicine Radiation OncologyJacksonvilleUSA
  2. 2.Department of Radiation OncologyRose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland ClinicClevelandUSA
  3. 3.Sunnybrook Odette Cancer Centre, Department of Radiation OncologyUniversity of TorontoTorontoCanada
  4. 4.University of Virginia, Departments of Neurological Surgery and Radiation OncologyCharlottesvilleUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology