Therapeutic Intranasal Delivery for Stroke and Neurological Disorders

  • Jun Chen
  • Jian Wang
  • Ling Wei
  • John H. Zhang

Part of the Springer Series in Translational Stroke Research book series (SSTSR)

Table of contents

  1. Front Matter
    Pages i-vi
  2. Raghuram Chava, Harikrishna Tandri
    Pages 1-7
  3. Zheng Zachory Wei, James Ya Zhang, Ling Wei
    Pages 9-26
  4. Jing Chen-Roetling, Raymond F. Regan
    Pages 43-55
  5. Tingting Huang, Amanda Smith, Jun Chen, Peiying Li
    Pages 65-73
  6. Chunhua Chen, Mengqin Zhang, Yejun Wu, Changman Zhou, Renyu Liu
    Pages 75-89
  7. Xinxin Wang, Fangxia Guan
    Pages 117-133
  8. Gang Zhang, Myles R. McCrary, Ling Wei
    Pages 135-147
  9. Back Matter
    Pages 149-153

About this book


The blood-brain-barrier prevented harmful materials entering the brain and in the meantime is a barricade to therapeutic drug delivery. Intranasal drug delivery to circumvent blood-brain-barrier was developed in the past, to take advantages of a secret passage from the olfactory epithelium into the brain—bypassing the tight junctions that encapsulated the brain from blood circulation. This timely publication of Therapeutic Intranasal Delivery for Stroke and Neurological Disorders presented some of the latest advances in intranasal delivery research, including transnasal hypothermia induction, stem cell intranasal transplantation, intranasal drug delivery in ischemic and hemorrhagic models, intranasal peptides delivery, intranasal tPA application in adults and children. 

Editors Jun Chen, Jian Wang, Ling Wei and John Zhang are professors from University of Pittsburgh, Johns Hopkins University, Emory University and Loma Linda University in USA.


blood-brain-barrier intranasal delivery neuroregeneration stem cells stroke

Editors and affiliations

  • Jun Chen
    • 1
  • Jian Wang
    • 2
  • Ling Wei
    • 3
  • John H. Zhang
    • 4
  1. 1.Department of NeurologyUniversity of PittsburghPittsburghUSA
  2. 2.Department of Anesthesiology and Critical Care MedicineThe Johns Hopkins University School of MedicineBaltimoreUSA
  3. 3.Departments of Anesthesiology and NeurologyEmory University School of MedicineAtlantaUSA
  4. 4.Department of PhysiologyLoma Linda University School of MedicineLoma LindaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-16713-4
  • Online ISBN 978-3-030-16715-8
  • Series Print ISSN 2363-958X
  • Series Online ISSN 2363-9598
  • Buy this book on publisher's site
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