The Biology of Senescence

A Translational Approach

  • Bernard Swynghedauw

Part of the Practical Issues in Geriatrics book series (PIG)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Bernard Swynghedauw
    Pages 1-7
  3. Bernard Swynghedauw
    Pages 9-23
  4. Bernard Swynghedauw
    Pages 25-36
  5. Bernard Swynghedauw
    Pages 37-46
  6. Bernard Swynghedauw
    Pages 47-58
  7. Bernard Swynghedauw
    Pages 59-82
  8. Bernard Swynghedauw
    Pages 89-94
  9. Bernard Swynghedauw
    Pages 95-97
  10. Bernard Swynghedauw
    Pages 99-100
  11. Back Matter
    Pages 101-121

About this book


This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it.

Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria.

Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.


Aging Senescent cell Age-related chronic diseases Telomerase Proteostasis

Authors and affiliations

  • Bernard Swynghedauw
    • 1
  1. 1.French Institute of Health and Medical ResearchParisFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine
  • Print ISBN 978-3-030-15110-2
  • Online ISBN 978-3-030-15111-9
  • Series Print ISSN 2509-6060
  • Series Online ISSN 2509-6079
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology