The DNA, RNA, and Histone Methylomes

  • Stefan Jurga
  • Jan Barciszewski

Part of the RNA Technologies book series (RNATECHN)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Hariharan Easwaran, Stephen B. Baylin
    Pages 27-52
  3. Emily C. Bruggeman, Bing Yao
    Pages 103-140
  4. Consuelo Walss-Bass, Gabriel R. Fries
    Pages 165-179
  5. Lara Kular, Maja Jagodic
    Pages 181-214
  6. Annakarina Mundorf, Nadja Freund
    Pages 215-227
  7. John Z. Cao, Anastasia E. Hains, Lucy A. Godley
    Pages 229-263
  8. Vivian Silva Kahl, Mónica Cappetta, Juliana Da Silva
    Pages 265-293
  9. Alessia Lucidi, Daniela Tomaselli, Dante Rotili, Antonello Mai
    Pages 295-331
  10. Mingjia Chen, Claus-Peter Witte
    Pages 333-351
  11. Miriam R. B. Porzberg, Bas J. G. E. Pieters, Jasmin Mecinović
    Pages 435-451
  12. Tian-Shi Wang, Jin-Ke Cheng, Qun-Ying Lei, Yi-Ping Wang
    Pages 521-541
  13. Francisco Saavedra, Ekaterina Boyarchuk, Francisca Alvarez, Geneviève Almouzni, Alejandra Loyola
    Pages 573-606
  14. Ronaldo de Carvalho Augusto, Céline Cosseau, Christoph Grunau
    Pages 607-624

About this book


This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions.

Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms.

This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.


Epigenetics DNA methylation RNA methylation Histone methylation Lysine methyltransferases Arginine methyltransferases

Editors and affiliations

  • Stefan Jurga
    • 1
  • Jan Barciszewski
    • 2
  1. 1.Nanobiomedical CenterAdam Mickiewicz UniversityPoznańPoland
  2. 2.Nanobiomedical CenterAdam Mickiewicz UniversityPoznańPoland

Bibliographic information

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