© 2019

Biological Responses to Nanoscale Particles

Molecular and Cellular Aspects and Methodological Approaches

  • Peter Gehr
  • Reinhard Zellner

Part of the NanoScience and Technology book series (NANO)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Manufacturing and Characterization of Materials

    1. Front Matter
      Pages 1-1
    2. Kateryna Loza, Matthias Epple
      Pages 3-27
    3. Christin Rengers, Nikolai Gaponik, Alexander Eychmüller
      Pages 29-51
    4. Banu Iyisan, Katharina Landfester
      Pages 53-84
    5. Kateryna Loza, Matthias Epple, Michael Maskos
      Pages 85-100
    6. Wye-Khay Fong, Thomas L. Moore, Sandor Balog, Dimitri Vanhecke, Laura Rodriguez-Lorenzo, Barbara Rothen-Rutishauser et al.
      Pages 101-150
  3. Membrane Transfer, Cellular Uptake and Intracellular Fate: Mechanisms and Detection Methods

    1. Front Matter
      Pages 151-151
    2. Barbara Rothen-Rutishauser, Joël Bourquin, Alke Petri-Fink
      Pages 153-170
    3. Nicole Schneider-Daum, Marius Hittinger, Xabier Murgia, Claus-Michael Lehr
      Pages 171-189
    4. Kleanthis Fytianos, Fabian Blank, Loretta Müller
      Pages 191-211
    5. Christina Graf, Eckart Rühl
      Pages 213-239
  4. Cellular Responses and Health Effects

    1. Front Matter
      Pages 241-241
    2. Stephen J. Evans, Gareth J. Jenkins, Shareen H. Doak, Martin J. D. Clift
      Pages 243-254
    3. Lorna Moll, Volker Mailänder
      Pages 255-279
    4. Andreas Frey, Katrin Ramaker, Niels Röckendorf, Barbara Wollenberg, Ingmar Lautenschläger, Gabriella Gébel et al.
      Pages 281-327
    5. Fanny Knorr, Alexa Patzelt, Martina Claudia Meinke, Anika Vogt, Ulrike Blume-Peytavi, Eckart Rühl et al.
      Pages 329-339
  5. Back Matter
    Pages 341-344

About this book


In this book the recent progress accumulated in studies of the interaction of engineered nanoparticles with cells and cellular constituents is presented. The focus is on manufacturing and characterization of nanosized materials, their interactions with biological molecules such as proteins, the mechanisms of transport across biological membranes as well as their effects on biological functions. Fundamental molecular and cellular aspects are in the foreground of the book. A further particularity is the interdisciplinary approach, including fields such as preparatory and analytical chemistry, biophysics and the physics of colloids, advanced microscopy and spectroscopy for in-situ detection of nanoparticles, cellular toxicology and nanomedicine.

Nanoscale particles are known to exhibit novel and unprecedented properties that make them different from their corresponding bulk materials. As our ability to control these properties is further advanced, a huge potential to create materials with novel properties and applications emerges. Although the technological and economic benefits of nanomaterials are indisputable, concerns have also been raised that nanoscale structuring of materials might also induce negative health effects. Unfortunately, such negative health effects cannot be deduced from the known toxicity of the corresponding macroscopic material. As a result, there is a major gap in the knowledge necessary for assessing their risk to human health.


Biological responses and health effects Membrane transfer and intercellular Trafficking Interactions of nanoparticles with proteins Membrane transfer mechanisms Nanomedicine Cellular uptake mechanisms Protein coronae Ligand shell particles Metal and oxide nanoparticles

Editors and affiliations

  • Peter Gehr
    • 1
  • Reinhard Zellner
    • 2
  1. 1.Institute of AnatomyUniversity of BernBernSwitzerland
  2. 2.Institute of Physical ChemistryUniversity of Duisburg-EssenEssenGermany

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