Cluster Headache and other Trigeminal Autonomic Cephalgias

  • Massimo Leone
  • Arne May

Part of the Headache book series (HEAD)

Table of contents

  1. Front Matter
    Pages i-x
  2. Gian Camillo Manzoni, Paola Torelli
    Pages 1-6
  3. Michael Bjørn Russell
    Pages 7-10
  4. Pietro Cortelli, Sabina Cevoli, Jesica Garcia, Miguel J. A. Láinez
    Pages 11-21
  5. Patricia Pozo-Rosich, Alessandro S. Zagami
    Pages 23-41
  6. Arn M. J. M. van den Maagdenberg, Anne Ducros
    Pages 43-56
  7. Laura H. Schulte, Stefania Ferraro
    Pages 67-90
  8. Trine Nielsen, Arne May, Tim P. Jürgens
    Pages 91-101
  9. Simon Akerman, Cristina Tassorelli
    Pages 103-115
  10. Stefan Evers
    Pages 131-134
  11. Andrea Negro, Paolo Martelletti
    Pages 135-151
  12. Michel Lantéri-Minet, Denys Fontaine, Delphine Magis
    Pages 153-167
  13. Lauren Ashley-Marie Schenck, Alberto Raggi, Domenico D’Amico, Alberto Proietti Cecchini, Frank Andrasik
    Pages 169-187
  14. Gianluca Coppola, Armando Perrotta, Francesco Pierelli, Giorgio Sandrini
    Pages 189-208
  15. Daniele Cazzato, Stine Maarbjerg, Lars Bendtsen, Giuseppe Lauria
    Pages 209-219
  16. Fu-Chi Yang, Todd J. Schwedt, Shuu-Jiun Wang
    Pages 221-236
  17. Anna Cohen, Giorgio Lambru
    Pages 237-255

About this book


This book provides essential insights into the current state of knowledge regarding the main aspects of cluster headache and trigeminal autonomic cephalgias. The first chapters focus on classification and clinical features, together with familial and genetic aspects. Relevant animal models and the putative role of key nervous structures as the hypothalamus, brainstem, diencephalon and sphenopalatine ganglion are reviewed.  Evidence gained from key molecules such as CGRP in animals and human headache models are discussed.

The book subsequently presents information on the various aspects of the pathophysiology of trigeminal autonomic cephalalgias for example regarding the implication of the trigeminovascular system and the facial autonomic reflexes of the brainstem. Further, it shares insights from imaging studies including functional magnetic resonance imaging and more advanced techniques, as well as brain stimulation procedures. Further chapters describe the current state of knowledge concerning drug treatment and the various neurostimulation procedures. Trigeminal neuralgia is also presented, due its close relationship with some short-term trigeminal autonomic cephalgias: a great deal can be learned from a better understanding of their differences and similarities. The same approach is then applied to cluster headache and migraine.

All chapters were written by respected experts in their fields, ensuring the book will provide an excellent source of up-to-date information and perspectives on trigeminal autonomic cephalgias and related disorders.  As such, it will be of considerable value for students, clinicians and pain researchers alike.


cluster headache paroxysmal hemicrania SUNCT pathophysiology treatment Neurostimulation Neuroimaging trigeminal autonomic cephalagias

Editors and affiliations

  • Massimo Leone
    • 1
  • Arne May
    • 2
  1. 1.Department of NeurologyNeuroalgology Unit, The Foundation of the Carlo Besta Neurological Institute, IRCCSMilanoItaly
  2. 2.Department of Systems NeuroscienceUniversity of HamburgHamburgGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-12437-3
  • Online ISBN 978-3-030-12438-0
  • Series Print ISSN 2197-652X
  • Series Online ISSN 2197-6538
  • Buy this book on publisher's site
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Internal Medicine & Dermatology