© 2019

Thymus Transcriptome and Cell Biology

  • Geraldo A. Passos

Table of contents

  1. Front Matter
    Pages i-xvii
  2. J. J. Muñoz, A. G. Zapata
    Pages 19-34
  3. Minoru Matsumoto, Pedro M. Rodrigues, Laura Sousa, Koichi Tsuneyama, Mitsuru Matsumoto, Nuno L. Alves
    Pages 35-65
  4. Kogulan Yoganathan, Edward L. Y. Chen, Jastaranpreet Singh, Juan Carlos Zúñiga-Pflücker
    Pages 67-115
  5. Daniella Arêas Mendes-da-Cruz, Carolina Valença Messias, Julia Pereira Lemos, Wilson Savino
    Pages 117-148
  6. Anette S. B. Wolff, Bergithe E. Oftedal
    Pages 191-214
  7. Geraldo A. Passos, Adriana B. Genari, Amanda F. Assis, Ana C. Monteleone-Cassiano, Eduardo A. Donadi, Ernna H. Oliveira et al.
    Pages 215-234
  8. Carlos Alberto Moreira-Filho, Silvia Yumi Bando, Fernanda Bernardi Bertonha, Magda Carneiro-Sampaio
    Pages 235-245
  9. Arnon Dias Jurberg, Vinicius Cotta-de-Almeida
    Pages 247-254
  10. Larissa Vasconcelos-Fontes, Rafaella Ferreira-Reis, João Ramalho Ortigão-Farias, Arnon Dias Jurberg, Vinicius Cotta-de-Almeida
    Pages 255-272
  11. Jarrod Dudakov, Michael L. Hun, Kahlia Wong, Georg Holländer, Ann P. Chidgey
    Pages 273-294
  12. João R. Lima-Júnior, Lucas C. M. Arruda, Maria Carolina de Oliveira, Kelen C. R. Malmegrim
    Pages 295-309
  13. Back Matter
    Pages 311-318

About this book


This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity.

The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.


Transcriptomics central immune tolerance, thymus gland autoimmunity Aire gene Crispr-Cas9.

Editors and affiliations

  • Geraldo A. Passos
    • 1
  1. 1.Laboratory of Genetics and Molecular Biology, Department of Basic and Oral Biology, School of Dentistry of Ribeirão PretoUniversity of São PauloRibeirão PretoBrazil

About the editors

Geraldo Aleixo Passos received his PhD degree in biochemistry (1988) from Ribeirão Preto Medical School, University of São Paulo, USP, Brazil. His postdoctoral studies were conducted at the Molecular Genetics Institute of Montpellier (CNRS), France (1992-94) with sequencing and physical mapping of the human immunoglobulin lambda locus on chromosome 22q11.2. During several years he worked in close collaboration in the microarray laboratory at Centre d´Immunologie de Marseille-Luminy (CIML, Marseille, France) (1999-2001) and then in the Unité INSERM 1090 in Marseille (2002-17) to study the large-scale gene expression in the thymus.  He is currently Associate Professor (Genetics and Molecular Biology) at School of Dentistry and Ribeirão Preto Medical School (USP, Campus of Ribeirão Preto, Brazil). He is the coordinator of the Molecular Immunogenetics Group. He was the adviser of two PhD theses awarded by Ministry of Education/CAPES: in 2008, one of his students received the CAPES Thesis Award and in 2010, another student received the distinction CAPES Thesis Honor in Genetics.

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