© 2019

Bioactive Lipids in Health and Disease

  • Andres Trostchansky
  • Homero Rubbo


  • Lipidomic analysis of key metabolic processes

  • Novel lipid- based therapeutic proposal for neurodegenerative diseases

  • 12 chapters and almost 50 color figures and tables


Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1127)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Structure, Characterization and Physicochemical Properties of Bioactive Lipids

    1. Front Matter
      Pages 1-1
    2. Matias N. Möller, Ernesto Cuevasanta, Florencia Orrico, Ana C. Lopez, Leonor Thomson, Ana Denicola
      Pages 3-19
    3. Priscilla Bento Matos Cruz Derogis, Adriano B. Chaves-Fillho, Sayuri Miyamoto
      Pages 21-35
  3. Signaling Cascades Mediated by Bioactive Lipids

    1. Front Matter
      Pages 37-37
    2. Bruno Araújo Serra Pinto, Lucas Martins França, Francisco Rafael Martins Laurindo, Antonio Marcus de Andrade Paes
      Pages 67-82
  4. Bioactive Lipids in Inflammatory and Cardiovascular Diseases

    1. Front Matter
      Pages 83-83
    2. Lucía Gonzalez-Perilli, Carolina Prolo, María Noel Álvarez
      Pages 85-95
    3. Antonio Marcus de Andrade Paes, Renato Simões Gaspar, Eduardo Fuentes, Sergio Wehinger, Iván Palomo, Andrés Trostchansky
      Pages 97-115
    4. Tamara Mazo, Veronica D’Annunzio, Martin Donato, Virginia Perez, Tamara Zaobornyj, Ricardo J. Gelpi
      Pages 117-130
    5. Gabriela Berg, Verónica Miksztowicz, Celina Morales, Magalí Barchuk
      Pages 131-143
  5. Role of Bioactive Lipids in Neurodegenerative Diseases

    1. Front Matter
      Pages 145-145
    2. Cecilia Chavarría, Andrés Trostchansky, Rosario Durán, Homero Rubbo, José M. Souza
      Pages 169-179
    3. Rubèn López-Vales, Samuel David
      Pages 181-194
  6. Back Matter
    Pages 195-198

About this book


The purpose of this book is to introduce the readers on the perspective of the role that unsaturated fatty acids and complex lipids play on health and disease. Bioactive lipids can be modified affecting membrane composition, structure and fluidity in addition to changes in cell signaling associated to lipid-protein (membrane receptors) interactions, issues that are addressed by the authors. This book analyzes key topics involving bioactive lipids and their role in normal signaling and the mechanisms of disease. The book navigates from structural studies of oxidized and non-oxidized lipids to the reactions and cell signaling processes that bioactive lipids play in cardiovascular and neurodegenerative diseases. The book contains the recent advances reported in the literature about lipidomics as well as the role that lipid-derived compounds exert on unfolded protein response and lipid metabolism and disease. This book represents a state of the art introduction to lipid metabolism from a biochemical to an in vivo overview being an useful tool for students and investigators. We hope the mechanistic observations on the role of bioactive lipids in health and disease serve a perspective to improve the existing treatments or propose new lipid-based pharmacology


Arachidonic acid inflammation cardiovascular diseases neurodegenerative diseases mass spectometry

Editors and affiliations

  • Andres Trostchansky
    • 1
  • Homero Rubbo
    • 2
  1. 1.Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO)Facultad de Medicina, Universidad de la RepúblicaMontevideoUruguay
  2. 2.Departamento de Bioquímica and Centro de Investigaciones Biomédicas (CEINBIO)Facultad de Medicina, Universidad de la RepúblicaMontevideoUruguay

About the editors

Andres Trostchansky is an associate professor of Biochemistry at the University de la Republica in Montevideo, Uruguay. He has received the Roberto Caldeyro Barcia Award in Biology.

Homero Rubbo is a professor in the department of Biochemistry at the University de la Republica in Montevideo, Uruguay.

Bibliographic information

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