© 2019

Sleep-Wake Neurobiology and Pharmacology

  • Hans-Peter Landolt
  • Derk-Jan Dijk
  • First Handbook of Experimental Pharmacology on sleep and wakefulness, in which the pharmacology of sleep is discussed very much in the context of current knowledge of sleep function, its neuroanatomical and neurochemical bases, and including circadian rhythmicity

  • Powerful state-of-the-art methodologies are covered, such as optogenetics and designer receptor manipulations

  • Sleep- and wake-promoting compounds are not discussed in isolation, but within a single volume, which helps the understanding of their interrelationships


Part of the Handbook of Experimental Pharmacology book series (HEP, volume 253)

Table of contents

  1. Front Matter
    Pages i-x
  2. Marcos G. Frank, H. Craig Heller
    Pages 3-34
  3. Pierre-Hervé Luppi, Patrice Fort
    Pages 35-58
  4. Emma K. O’Callaghan, Edward W. Green, Paul Franken, Valérie Mongrain
    Pages 59-81
  5. Laura E. McKillop, Vladyslav V. Vyazovskiy
    Pages 97-121
  6. Antoine Adamantidis, Anita Lüthi
    Pages 125-151
  7. Christophe Varin, Patricia Bonnavion
    Pages 153-206
  8. Hans-Peter Landolt, Sebastian C. Holst, Amandine Valomon
    Pages 207-241
  9. Kai Spiegelhalder, Christoph Nissen, Dieter Riemann
    Pages 261-276
  10. W. Wisden, X. Yu, N. P. Franks
    Pages 279-304
  11. Megan Alston, Sean W. Cain, Shantha M. W. Rajaratnam
    Pages 305-319
  12. Michael Lazarus, Jiang-Fan Chen, Zhi-Li Huang, Yoshihiro Urade, Bertil B. Fredholm
    Pages 359-381
  13. Stephen B. Hladky, Margery A. Barrand
    Pages 385-423

About this book


The chapter 'Sleep Physiology, Circadian Rhythms, Waking Performance and the Development of Sleep-Wake Therapeutics' available open access under a CC BY 4.0 license at


Sleep Sleep disorders Circadian rhythms Receptor pharmacology Optogenetics Pharmacogenetics DREADD

Editors and affiliations

  • Hans-Peter Landolt
    • 1
  • Derk-Jan Dijk
    • 2
  1. 1.Human Sleep Psychopharmacology Laboratory, Institute of Pharmacology and ToxicologyUniversity of ZürichZürichSwitzerland
  2. 2.Surrey Sleep Research Centre, Faculty of Health and Medical SciencesUniversity of SurreyGuildfordUK

Bibliographic information

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