Activity-Based Protein Profiling

  • Benjamin F. Cravatt
  • Ku-Lung Hsu
  • Eranthie Weerapana

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 420)

Table of contents

  1. Front Matter
    Pages i-x
  2. Shabnam Sharifzadeh, Joshua D. Shirley, Erin E. Carlson
    Pages 23-48
  3. Hiren V. Patel, Michael Li, Jessica C. Seeliger
    Pages 49-72
  4. Yekaterina Kovalyova, Stavroula K. Hatzios
    Pages 73-91
  5. Gerbrand J. van der Heden van Noort, Huib Ovaa
    Pages 111-130
  6. Geneviève F. Desrochers, John Paul Pezacki
    Pages 131-154
  7. Henry J. Benns, Edward W. Tate, Matthew A. Child
    Pages 155-174
  8. Adam L. Borne, Tao Huang, Rebecca L. McCloud, Boobalan Pachaiyappan, Timothy N. J. Bullock, Ku-Lung Hsu
    Pages 175-210
  9. Venkatesh V. Nemmara, Paul R. Thompson
    Pages 233-251
  10. Suravi Chakrabarty, Jan Pascal Kahler, Merel A. T. van de Plassche, Roeland Vanhoutte, Steven H. L. Verhelst
    Pages 253-281
  11. Sebastiaan T. A. Koenders, Berend Gagestein, Mario van der Stelt
    Pages 283-319
  12. Fumihiro Ishikawa, Genzoh Tanabe, Hideaki Kakeya
    Pages 321-349
  13. Daniel K. Nomura, Thomas J. Maimone
    Pages 351-374
  14. Keriann M. Backus
    Pages 375-417

About this book


This volume provides a collection of contemporary perspectives on using activity-based protein profiling (ABPP) for biological discoveries in protein science, microbiology, and immunology. A common theme throughout is the special utility of ABPP to interrogate protein function and small-molecule interactions on a global scale in native biological systems. Each chapter showcases distinct advantages of ABPP applied to diverse protein classes and biological systems. As such, the book offers readers valuable insights into the basic principles of ABPP technology and how to apply this approach to biological questions ranging from the study of post-translational modifications to targeting bacterial effectors in host-pathogen interactions.


Penicillin-binding proteins Poly-ADP-ribosylation Host-virus interactions Intramembrane proteases Cysteine profiling Lysine profiling Endocannabinoid enzymes ABPP

Editors and affiliations

  • Benjamin F. Cravatt
    • 1
  • Ku-Lung Hsu
    • 2
  • Eranthie Weerapana
    • 3
  1. 1.Department of ChemistryThe Scripps Research InstituteLa JollaUSA
  2. 2.Department of ChemistryUniversity of VirginiaCharlottesvilleUSA
  3. 3.Department of ChemistryBoston CollegeChestnut HillUSA

Bibliographic information

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