© 2018

Mechanisms of Drug Resistance in Cancer Therapy

  • Mario Mandalà
  • Emanuela Romano


  • Gives an updated overview on the possible reasons of failure of new and promising therapeutic opportunities

  • Provides extensive discussions of issues including pharmacodynamic and pharmacokinetic mechanisms of resistance, alterations in the drug target, activation of prosurvival pathways, ineffective induction of cell death, and plasticity of microenvironment

  • Covers the diverse perspectives of basic scientists, clinical pharmacologists and clinicians


Part of the Handbook of Experimental Pharmacology book series (HEP, volume 249)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Benedetta Colmegna, Lavinia Morosi, Maurizio D’Incalci
    Pages 1-12
  3. Diego O. Croci, Santiago P. Mendez-Huergo, Juan P. Cerliani, Gabriel A. Rabinovich
    Pages 31-61
  4. Francesco Facchinetti, Claudia Proto, Roberta Minari, Marina Garassino, Marcello Tiseo
    Pages 63-89
  5. Matthew Winder, Amaya Virós
    Pages 91-108
  6. Rodrigo N. Ramos, Eliane Piaggio, Emanuela Romano
    Pages 109-128
  7. Giuseppe Curigliano
    Pages 161-180
  8. Alfredo Berruti, Alberto Dalla Volta
    Pages 181-194
  9. Federico Lussana, Tamara Intermesoli, Paola Stefanoni, Alessandro Rambaldi
    Pages 231-250
  10. Athanasios Papadas, Fotis Asimakopoulos
    Pages 251-288

About this book


A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.


Drug resistance Drug mechanisms Targeted therapy Immunotherapy Chemotherapy

Editors and affiliations

  • Mario Mandalà
    • 1
  • Emanuela Romano
    • 2
  1. 1.Department of Oncology and HematologyPapa Giovanni XXIII HospitalBergamoItaly
  2. 2.Department of Oncology, INSERM Res Unit 932Institut CurieParis Cedex 05France

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