Mechanisms of Drug Resistance in Cancer Therapy

  • Mario Mandalà
  • Emanuela Romano

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 249)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Benedetta Colmegna, Lavinia Morosi, Maurizio D’Incalci
    Pages 1-12
  3. Diego O. Croci, Santiago P. Mendez-Huergo, Juan P. Cerliani, Gabriel A. Rabinovich
    Pages 31-61
  4. Francesco Facchinetti, Claudia Proto, Roberta Minari, Marina Garassino, Marcello Tiseo
    Pages 63-89
  5. Matthew Winder, Amaya Virós
    Pages 91-108
  6. Rodrigo N. Ramos, Eliane Piaggio, Emanuela Romano
    Pages 109-128
  7. Giuseppe Curigliano
    Pages 161-180
  8. Alfredo Berruti, Alberto Dalla Volta
    Pages 181-194
  9. Federico Lussana, Tamara Intermesoli, Paola Stefanoni, Alessandro Rambaldi
    Pages 231-250
  10. Athanasios Papadas, Fotis Asimakopoulos
    Pages 251-288

About this book


A major objective of this book is to reveal unprecedented opportunities to understand and overcome drug resistance through the clinical assessment of rational therapeutic drug combinations and the use of predictive and prognostic biomarkers to enable patient stratification and tailor treatments. It offers to the readers an updated overview on the possible reasons of failure of new and promising therapeutic opportunities.


Drug resistance Drug mechanisms Targeted therapy Immunotherapy Chemotherapy

Editors and affiliations

  • Mario Mandalà
    • 1
  • Emanuela Romano
    • 2
  1. 1.Department of Oncology and HematologyPapa Giovanni XXIII HospitalBergamoItaly
  2. 2.Department of Oncology, INSERM Res Unit 932Institut CurieParis Cedex 05France

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-10506-8
  • Online ISBN 978-3-030-10507-5
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods