© 2019

Soft Probes for Bio-electrochemical Imaging


Part of the Springer Theses book series (Springer Theses)

About this book


This book discusses the development of various reliable scanning electrochemical microscopy (SECM) imaging techniques for studying the distribution of biomarkers and nanomaterials in thin and thick animal samples, plant antioxidant (AO) defense systems, as well as human melanoma. The authors demonstrate that SECM could improve the diagnosis and understanding of different melanoma stages on the basis of highly resolved maps of the tyrosinase distribution. Tyrosinase is the key enzyme involved in fruit maturation and is a biomarker for melanoma. As such the book presents various tyrosinase SECM detection strategies developed for the analysis of the spatial distribution of tyrosinase in melanoma and in banana samples. It describes the first imaging of the redox active proteins within the entire mouse heart with an SECM system using a spider probe composed of eight independent microelectrodes. Further, it investigates distributions of injected graphene nanoribbons (GONRs) for drug delivery by Soft-Probe-SECM. Lastly, the book outlines a non-invasive electrochemical strategy for mapping the AO activity of apple peel using Soft-Probe-SECM.


Scanning Electrochemical Microscopy (SECM) Microelectrode Soft Probe Spider Probe Tyrosinase Melanoma Graphene Oxide Nanoribbon Thick Tissue Contact Mode Scanning Feedback Mode Generation Collection Mode Bioimaging Biosensing

Authors and affiliations

  1. 1.Chemistry and Chemical EngineeringÉcole Polytechnique Fédérale de LausanneSionSwitzerland

About the authors

Dr. Tzu-En Lin is currently a postdoctoral researcher with a specialization in electrochemistry at École Polytechnique Fédérale de Lausanne, Switzerland (EPFL). She obtained her PhD degree from EPFL and her master’s degree from National Taiwan University. Her supervisor is Prof. Hubert Girault, an expert in physical and analytical chemistry, battery technology and hydrogen car development. She was admitted to the US “Stanford University-EPFL exchange program” as a visiting scholar. Her work on “banana and skin cancer” has been reported worldwide. 

Bibliographic information

Industry Sectors
Chemical Manufacturing
Consumer Packaged Goods