Gastric Cancer In The Precision Medicine Era

Diagnosis and Therapy

  • Vincenzo Canzonieri
  • Antonio Giordano

Part of the Current Clinical Pathology book series (CCPATH)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Gastric Tumorigenesis

    1. Front Matter
      Pages 1-1
    2. Stefania Zanussi, Mariateresa Casarotto, Chiara Pratesi, Paolo De Paoli
      Pages 3-23
    3. Valli De Re, Riccardo Dolcetti
      Pages 25-40
  3. Clinical and Pathological Characteristics

    1. Front Matter
      Pages 41-41
    2. Renato Cannizzaro, Raffaella Magris, Stefania Maiero, Paola Spessotto, Valli De Re, Mara Fornasarig
      Pages 43-52
    3. Rossella Rotondo, Flavio Rizzolio, Tiziana Perin, Massimiliano Berretta, Fabrizio Zanconati, Antonio Giordano et al.
      Pages 53-82
    4. Vincenzo Canzonieri, Federica Rao, Tiziana Perin, Lara Alessandrini, Angela Buonadonna, Giulio Bertola et al.
      Pages 83-106
    5. Agostino Steffan, Silvia Cervo, Valentina Fanotto, Fabio Puglisi
      Pages 107-117
  4. Gastric Cancer Therapy: Multimodal Treatment Approach

    1. Front Matter
      Pages 119-119
    2. Angela Buonadonna, Gian Maria Miolo, Valentina Fanotto, Federico Navarria, Elisa Palazzari, Claudio Belluco et al.
      Pages 121-132
    3. Antonino De Paoli, Federico Navarria, Elisa Palazzari, Matteo Olivieri, Claudio Belluco, Michela Guardascione et al.
      Pages 133-145
    4. Claudio Belluco, Matteo Olivieri, Andrea Lauretta, Danilo Antona, Antonino De Paoli, Federico Navarria et al.
      Pages 147-152
  5. Evolving Treatment Landscape in Gastric Cancer

    1. Front Matter
      Pages 153-153
    2. Lara Alessandrini, Melissa Manchi, Fabrizio Italia, Tiziana Perin, Vincenzo Canzonieri
      Pages 155-172
  6. Future Medicine in Gastric Cancer

    1. Front Matter
      Pages 173-173
    2. Federica Rao, Flavio Rizzolio, Clara Rizzardi, Tiziana Perin, Vincenzo Canzonieri
      Pages 175-187
    3. Riccardo Dolcetti, Valli De Re
      Pages 189-212
    4. Nayla Mouawad, Maguie El Boustani, Vincenzo Canzonieri, Isabella Caligiuri, Flavio Rizzolio
      Pages 213-247
  7. Back Matter
    Pages 249-256

About this book


This book provides a comprehensive, state-of-the art review and serves as an overview of the different aspects of gastric cancer. The first section aims to clarify the main aspects of tumorigenesis, such as the role of inflammation linked to the presence of H. Pylori infection, and the genetic and epigenetic mechanisms so far known. Secondly, an exhaustive overview of the diagnosis of gastric cancer from a clinical/endoscopic and pathologic perspective will be illustrated. The second section includes the pathological and clinical features and contains information regarding the most recent tissue and serological biomarkers in these neoplasms. The three successive sections are intended to provide the “state of art” of multimodal treatment approaches to gastric cancer, i.e. standard and novel surgical aspects, common and innovative chemo and radio protocols and modern targeted therapies. Novel molecular classifications are under consideration to improve diagnostic and prognostic definitions and to prospect future treatments based on the use of immunotherapies and innovative molecules such as non-coding RNA and nanoparticles.

Gastric Cancer in the Precision Medicine Era serves as a useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy.  It provides a concise yet comprehensive summary of the current status of the field that helps guide patient management and stimulates investigative efforts.  All chapters are written by experts in their fields and includes the most up to date scientific and clinical information.


Gastric tumorigenesis targeted therapy molecular classification Serum biomarkers epigenetic mechanisms

Editors and affiliations

  • Vincenzo Canzonieri
    • 1
  • Antonio Giordano
    • 2
  1. 1.Pathology Unit and BiobankCRO-Aviano, IRCCS, National Cancer InstituteAvianoItaly
  2. 2.Sbarro Institute for Cancer, Research and Molecular Medicine, Department of BiologyTemple UniversityPhiladelphiaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Humana, Cham
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-3-030-04860-0
  • Online ISBN 978-3-030-04861-7
  • Series Print ISSN 2197-781X
  • Series Online ISSN 2197-7828
  • Buy this book on publisher's site
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Health & Hospitals