© 2020

Subarachnoid Hemorrhage

Neurological Care and Protection

  • Robert D. Martin
  • Warren Boling
  • Gang Chen
  • John H. Zhang
  • Summarizes the latest studies on acute and delayed neurovascular injuries after subarachnoid hemorrhage

  • Covers new pilot treatments, clinical trials, academic and industrial interactions

  • Discusses animal models used to study acute and delayed neurovascular events


Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 127)

Table of contents

  1. Front Matter
    Pages i-x
  2. Bryce Weir
    Pages 1-10
  3. Nicolas K. Khattar, Esther Bak, Andrew C. White, Robert F. James
    Pages 15-19
  4. Warren Boling, Lydia Kore
    Pages 21-25
  5. Basic Science Section

    1. Front Matter
      Pages 27-27
    2. Alejandra N. Martinez, Crissey L. Pascale, Peter S. Amenta, Rachel Israilevich, Aaron S. Dumont
      Pages 29-34
    3. Tomohiro Aoki, Haruka Miyata, Yu Abekura, Hirokazu Koseki, Kampei Shimizu
      Pages 35-41
    4. Fumi Nakano, Lei Liu, Fumihiro Kawakita, Yoshinari Nakatsuka, Hirofumi Nishikawa, Takeshi Okada et al.
      Pages 43-46
    5. Jinjin Wang, Yin Liu, Haitao Shen, Haiying Li, Zhong Wang, Gang Chen
      Pages 47-54
    6. Fumi Nakano, Fumihiro Kawakita, Lei Liu, Yoshinari Nakatsuka, Hirofumi Nishikawa, Takeshi Okada et al.
      Pages 55-58
    7. Hirofumi Nishikawa, Fumi Nakano, Lei Liu, Yoshinari Nakatsuka, Takeshi Okada, Masato Shiba et al.
      Pages 65-68
    8. Takeshi Okada, Liu Lei, Hirofumi Nishikawa, Fumi Nakano, Yoshinari Nakatsuka, Hidenori Suzuki
      Pages 77-81
    9. Jesse J. Liu, Jeffrey S. Raskin, Robin McFarlane, Ravi Samatham, Justin S. Cetas
      Pages 83-89
    10. Hidenori Suzuki, Masashi Fujimoto, Fumihiro Kawakita, Lei Liu, Fumi Nakano, Hirofumi Nishikawa et al.
      Pages 91-96
    11. Zelong Zheng, Michael Schoell, Renan Sanchez-Porras, Christian Diehl, Andreas Unterberg, Oliver W. Sakowitz
      Pages 97-103
    12. Juyi Zhang, Peng Zhang, Chengjie Meng, Baoqi Dang, Haiying Li, Haitao Shen et al.
      Pages 105-119
    13. Zhiyuan Vera Zheng, Ping Kuen Lam, Wai Sang Poon, Kwok Chu George Wong
      Pages 121-125

About this book


This book highlights the latest developments in acute and delayed neurovascular injury studies including delayed cerebral vasospasm, early brain injury, micro-circulation compromise, spreading cortical depolarization, neuroinflammation, and long-term cognitive dysfunctions after subarachnoid hemorrhage. About 32 chapters cover original presentations from the 14th international conference on neurovascular events after subarachnoid hemorrhage, held in Los Angeles in October 2017. Neurosurgeons, neurologists, and neuro-ICU practitioners discuss clinical observations, new pilot treatments, clinical trials, academic and industrial interactions, including surgical and endovascular approaches, brain injury monitoring, new developments in brain imaging, ICU management, early brain injury scales and management, counter cortical depolarization management and anti-inflammation management. In addition, animal models used to study acute and delayed neurovascular events, the basic mechanisms of vascular, neuronal, and CSF physiology, new experimental treatment strategies, new frontiers in the treatment of neurovascular injuries, and new research directions are discussed. 


Cerebral Vasospasm Early Brain Injury Acute Neurovascular Event Delayed Cerebral Vasospasm Neuroinflammation Surgical and Endovascular Approaches Brain Imaging Animal Models

Editors and affiliations

  • Robert D. Martin
    • 1
  • Warren Boling
    • 2
  • Gang Chen
    • 3
  • John H. Zhang
    • 4
  1. 1.Department of AnethesiologyLoma Linda University Medical CenterLoma LindaUSA
  2. 2.Department of NeurosurgeryLoma Linda University Medical CenterLoma LindaUSA
  3. 3.Department of NeurosurgeryFirst Affiliated Hospital of Soochow UniversitySuzhouChina
  4. 4.Department of Anesthesiology and PhysiologyLoma Linda University Medical CenterLoma LindaUSA

About the editors

Robert D. Martin, M.D. is Professor of the Floyd S. Brauer Chair in Anesthesiology at Loma Linda University, Loma Linda, California and has held this position since 2004.  He is a member of the Board of Trustees of Loma Linda University.  He is Board Certified in Pain Medicine and Anesthesiology.  His primary clinical interests have been in the areas of Cardiac Anesthesiology and Pain.  Dr. Martin was a pioneer in developing anesthesiology protocols for infant heart transplantation.

Warren Boling, M.D., FRCSC, FRACS is Professor, Program Director, and Chairman of the Department of Neurosurgery at Loma Linda University, Loma Linda, CA. He is the past president of the Society of Brain Mapping and Therapeutics and a member of the SBMT Board of Directors. He is a member of the Faculty Medical Group of Loma Linda University Board of Directors. Dr Boling is an academic neurosurgeon and investigator, his primary interests are in the research and neurosurgical aspects of brain imaging, epilepsy, neuro-oncology, and international medicine. He is an expert on the fine topographic detail of human neuro-anatomy, which has led to the identification of anatomical and functional relationships in the human brain.

Gang Chen, M.D., Ph.D. is professor and vice Director of the Department of Neurosurgery at The First Affiliated Hospital of Soochow University, Suzhou, China. He also severs as Director of the Translational Stroke Research Team, and as Chair of the Division of Science & Technology. Dr. Chen’s research focuses on subarachnoid hemorrhage (SAH), which is a violent disease affecting the human health. In SAH, Dr. Chen has put forward “Right time, Right therapy” therapeutic principle. He continues to identify novel regulatory mechanisms in candidate proteins such as CyPA/CD147, neurexin-1β/neuroligin-1, etc., and to evaluate the current development, challenges and potential clinical translation of these researches. Dr. Chen’s research efforts have been supported by grants from the National Natural Science Foundation of China.

John H. Zhang, M.D., Ph.D. (Editor) Loma Linda University Medical School, Loma Linda, CA, is currently a Professor of Anesthesiology, Neurosurgery, Neurology, Basic Sciences (Physiology & Pharmacology), Pathology & Human Anatomy, and Nursing at Loma Linda University Medical Center. He also serves as Director of the Center for Brain Hemorrhage Research, as Vice-Chair of the Department of Basic Sciences (Chief of Division of Physiology), as Director of the Physiology Graduate Training Program, and as Director of the Basic Science Research Division in Anesthesiology. Dr. Zhang’s research efforts have been supported by grants from the American Heart Association, National Institute of Health, and Department of Defense as well as other regional foundations and industry. Dr. Zhang has published more than 600 peer-reviewed articles and has been invited to speak in meetings, seminars, and grand rounds more than 300 times.

Bibliographic information

  • Book Title Subarachnoid Hemorrhage
  • Book Subtitle Neurological Care and Protection
  • Editors Robert D. Martin
    Warren Boling
    Gang Chen
    John H. Zhang
  • Series Title Acta Neurochirurgica Supplement
  • Series Abbreviated Title Acta Neurochirurgica Supplement
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2020
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-030-04614-9
  • eBook ISBN 978-3-030-04615-6
  • Series ISSN 0065-1419
  • Series E-ISSN 2197-8395
  • Edition Number 1
  • Number of Pages X, 235
  • Number of Illustrations 34 b/w illustrations, 36 illustrations in colour
  • Topics Neurosurgery
  • Buy this book on publisher's site
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