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© 2019

Cholesterol Modulation of Protein Function

Sterol Specificity and Indirect Mechanisms

  • Avia Rosenhouse-Dantsker
  • Anna N. Bukiya
  • Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function

  • Contributors are well-known experts in their fields and provide international perspective

  • Research will be invaluable across several areas from biochemistry to nutrition

Book

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1115)

Table of contents

  1. Front Matter
    Pages i-x
  2. Sterol Specificity in Modulating Protein Function

    1. Front Matter
      Pages 1-1
    2. Md. Jafurulla, G. Aditya Kumar, Bhagyashree D. Rao, Amitabha Chattopadhyay
      Pages 21-52
  3. Indirect Modulation of Protein Function by Cholesterol

  4. Back Matter
    Pages 191-197

About this book

Introduction

In this book, renowned scientists describe the role of steroid chirality and modification of lipid membrane physical properties in the modulation of G protein-coupled receptors and ion channels. The application of commonly-used technical approaches such as mass spectrometry and nucleic magnetic resonance transfer spectroscopy for studies on cholesterol distribution and alteration of lipid bilayer characteristics is also discussed.

This book offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via mechanisms that extend beyond lipid-protein direct interactions.  In the first part, the chapters introduce the reader to the use of the chemical derivatives of cholesterol as a valuable laboratory tool in the studies of cholesterol-driven modulation of protein function. In the second part, examples of cholesterol-induced changes in membrane physical characteristics are presented and discussed in light of their multifaceted contribution to the effect of cholesterol on protein function.

The book will be of interest to undergraduate and graduate students as well as basic science and medical researchers with a keen interest in the biophysical properties of cholesterol and physiological consequences of cholesterol presence in biological systems.

Keywords

cholesterol modulation protein function membrane cholesterol lipid sensors cholesterol distribution

Editors and affiliations

  • Avia Rosenhouse-Dantsker
    • 1
  • Anna N. Bukiya
    • 2
  1. 1.Department of ChemistryUniversity of IllinoisChicagoUSA
  2. 2.The University of Tennessee Health Science CenterMemphisUSA

About the editors

Avia Rosenhouse-Dantsker, D.Sc., is a Clinical Assistant Professor at the University of Illinois at Chicago. Her research background ranges from quantum theory and computational biology to biophysical chemistry, molecular biology and electrophysiology. Her current research employs experimental and computational approaches to elucidate structural and functional mechanisms of protein modulation with a special emphasis on the modulation of ion channels by lipids (e.g. cholesterol, phosphoinositides, and others). Dr. Rosenhouse-Dantsker is a member of the Biophysical Society and the American Society for Biochemistry and Molecular Biology. She is currently also serving as a co-Editor on a book on the Direct Mechanisms in Cholesterol Modulation of Protein Function.

Anna N. Bukiya, Ph.D., is an Associate Professor at the Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center. Her scientific interests lie in the field of lipid modulation of ionic currents and ion channel sensitivity to alcohol starting from in utero development and spanning into adulthood. Current studies employ an array of computational, biochemical, electrophysiological, and integrative approaches. Dr. Anna Bukiya is a member of the Biophysical Society, and the American Society for Pharmacology and Experimental Therapeutics (Division of Cardiovascular Pharmacology). She is currently also serving as a co-Editor on a book on the Direct Mechanisms in Cholesterol Modulation of Protein Function.

Bibliographic information

  • Book Title Cholesterol Modulation of Protein Function
  • Book Subtitle Sterol Specificity and Indirect Mechanisms
  • Editors Avia Rosenhouse-Dantsker
    Anna N. Bukiya
  • Series Title Advances in Experimental Medicine and Biology
  • Series Abbreviated Title Adv Exp Med Biol
  • DOI https://doi.org/10.1007/978-3-030-04278-3
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-04277-6
  • eBook ISBN 978-3-030-04278-3
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages X, 197
  • Number of Illustrations 12 b/w illustrations, 33 illustrations in colour
  • Topics Proteomics
    Protein Science
    Membrane Biology
    Molecular Medicine
  • Buy this book on publisher's site
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