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© 2018

Surface Enhanced Raman Spectroscopy for Biophysical Applications

Using Plasmonic Nanoparticle Assemblies

Book

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Claudia Fasolato
    Pages 1-8
  3. Claudia Fasolato
    Pages 137-139
  4. Back Matter
    Pages 141-155

About this book

Introduction

The book explores the phenomenon of surface-enhanced Raman scattering (SERS), the huge amplification of Raman signal from molecules in the proximity of a metallic nanostructured surface, allowing readers to gain an in-depth understanding of the mechanisms affecting the spectroscopic response of SERS-active systems for effective applications. SERS spectroscopy is an ultrasensitive analytical technique with great potential for applications in the field of biophysics and nanomedicine. As examples, the author presents the design of nanocolloid-based SERS-active substrates for molecular sensing and of a folate-based SERS-active nanosensor capable of selectively interacting with cancer cells, enabling cancer diagnostics and therapy at the single-cell level. The author also suggests novel paths for the systematization of the SERS nanosystem design and experimental protocols to maximize sensitivity and reproducibility, which is essential when real-world biomedical applications are the goal of the study. With a combined approach, both fundamental and applied, and a detailed analysis of the state of the art, this book provides a valuable overview both for students new to SERS spectroscopy and for experts in the field.

Keywords

Surface Enhanced Raman Scattering Raman Spectroscopy in Biophysics Biophysical Analysis Cancer Nanomedicine SERS Substrates Nanovectors Folate-Based Nanosensor 4-Aminothiophenol

Authors and affiliations

  1. 1.Dipartimento di Fisica e GeologiaUniversità degli Studi di PerugiaPerugiaItaly

About the authors

Claudia Fasolato received her Master Degree in Condensed Matter Physics in October 2013. She started her Ph.D. in Sapienza University in November 2013 working on plasmonic nanoparticle assemblies for Surface Enhanced Raman Spectroscopy under the supervision of Prof. P. Postorino. In February 2017, she was awarded her Ph.D. in Physics summa cum laude. Since April 2017, she has worked as a postdoc in the Nanophononics Group of Prof. I. Zardo at the University of Basel.

Bibliographic information