© 2018

HIV-1 Latency

  • Guido Silvestri
  • Mathias Lichterfeld
  • Offers new insights into the fascinating area of HIV latency and persistence from multiple perspectives and scientific directions

  • Provides in-depth analyses of current concepts, paradigms and ideas that drive the HIV-1 cure agenda

  • Identifies areas that require specific emphasis in future studies


Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 417)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Gilles Darcis, Benoit Van Driessche, Sophie Bouchat, Frank Kirchhoff, Carine Van Lint
    Pages 1-22
  3. Janet D. Siliciano, Robert F. Siliciano
    Pages 23-41
  4. Rebecca T. Veenhuis, Joel N. Blankson
    Pages 43-67
  5. Lucio Gama, Celina Abreu, Erin N. Shirk, Suzanne E. Queen, Sarah E. Beck, Kelly A. Metcalf Pate et al.
    Pages 111-130
  6. Alison L. Hill
    Pages 131-156
  7. Elena Bruzzesi, Irini Sereti
    Pages 157-180
  8. Denise C. Hsu, Jintanat Ananworanich
    Pages 181-210
  9. Christopher W. Peterson, Hans-Peter Kiem
    Pages 211-248

About this book


This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.


virus reservoirs antiviral immune response HIV eradication Cd4+ T cell subsets latency reactivation antiretroviral therapy

Editors and affiliations

  • Guido Silvestri
    • 1
  • Mathias Lichterfeld
    • 2
  1. 1.School of MedicineEmory UniversityAtlantaUSA
  2. 2.The Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and HarvardBostonUSA

About the editors

Guido Silvestri

Emory University School of Medicine, Atlanta, GA 30329, USA

Mathias Lichterfeld

The Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and Harvard, Boston, MA, USA

Bibliographic information

  • Book Title HIV-1 Latency
  • Editors Guido Silvestri
    Mathias Lichterfeld
  • Series Title Current Topics in Microbiology and Immunology
  • Series Abbreviated Title Current Topics in Microbiology and Immunology
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-02815-2
  • Softcover ISBN 978-3-030-13214-9
  • eBook ISBN 978-3-030-02816-9
  • Series ISSN 0070-217X
  • Series E-ISSN 2196-9965
  • Edition Number 1
  • Number of Pages VII, 248
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
  • Buy this book on publisher's site
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