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HIV-1 Latency

  • Guido Silvestri
  • Mathias Lichterfeld
Book

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 417)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Gilles Darcis, Benoit Van Driessche, Sophie Bouchat, Frank Kirchhoff, Carine Van Lint
    Pages 1-22
  3. Janet D. Siliciano, Robert F. Siliciano
    Pages 23-41
  4. Rebecca T. Veenhuis, Joel N. Blankson
    Pages 43-67
  5. Lucio Gama, Celina Abreu, Erin N. Shirk, Suzanne E. Queen, Sarah E. Beck, Kelly A. Metcalf Pate et al.
    Pages 111-130
  6. Alison L. Hill
    Pages 131-156
  7. Elena Bruzzesi, Irini Sereti
    Pages 157-180
  8. Denise C. Hsu, Jintanat Ananworanich
    Pages 181-210
  9. Christopher W. Peterson, Hans-Peter Kiem
    Pages 211-248

About this book

Introduction

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.

Keywords

virus reservoirs antiviral immune response HIV eradication Cd4+ T cell subsets latency reactivation antiretroviral therapy

Editors and affiliations

  • Guido Silvestri
    • 1
  • Mathias Lichterfeld
    • 2
  1. 1.School of MedicineEmory UniversityAtlantaUSA
  2. 2.The Brigham and Women’s Hospital and the Ragon Institute of MGH, MIT and HarvardBostonUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-02816-9
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-030-02815-2
  • Online ISBN 978-3-030-02816-9
  • Series Print ISSN 0070-217X
  • Series Online ISSN 2196-9965
  • Buy this book on publisher's site
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