© 2019

Regulatory and Economic Aspects in Oncology

  • Evelyn Walter


  • Addresses key issues relating to the increasing expenditure on new targeted cancer therapies

  • Discusses the evaluation of benefits, harms, and costs

  • Examines drug pricing and drug price regulation in different countries

  • Explores the changing landscape in marketing authorization and its regulation


Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 213)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Evelyn Walter
    Pages 1-5
  3. Clement Francois, Junwen Zhou, Michał Pochopien, Leila Achour, Mondher Toumi
    Pages 25-38
  4. Szymon Jarosławski, Eve Hanna, Monique Dabbous, Lylia Chachoua, Mondher Toumi
    Pages 39-55
  5. Mondher Toumi, Szymon Jarosławski, Christos Chouhaid, Bruno Fallissard, P. Auquier
    Pages 57-65
  6. Evelyn Walter
    Pages 85-108
  7. Daria Korchagina, Szymon Jaroslawski, Guy Jadot, Mondher Toumi
    Pages 109-142
  8. William Green, Matthew Taylor
    Pages 143-151
  9. Patricia M. Danzon
    Pages 153-167
  10. Nikolaus Knoepffler, Jürgen Zerth, Martin O’Malley
    Pages 189-205

About this book


This book explores a wide range of topics of importance to all those who have an interest in economic methods for assessment of the efficacy and effectiveness of new cancer treatments and in regulatory measures relating to the marketing authorization and pricing of such treatments. It also examines drug pricing and drug price regulation in different countries and explores the changing landscape in marketing authorization and its regulation. These issues are becoming increasingly important with the introduction of expensive targeted cancer therapies, which are placing a substantial strain on healthcare healthcare budgets. Payer authorities have to determine whether the use of targeted therapies yields clinical benefits that justify their cost. In the simplest terms, cost-effectiveness analysis quantifies the ratio between the extent to which an intervention raises healthcare costs and the extent to which it improves health outcomes. Rigorous cost-effectiveness analyses translate all health outcomes into quality-adjusted life years. On the other hand, in order to sustain innovation, price regulation must be coupled with efforts to ensure that drug companies are still able to recoup their investments in high-risk and high-cost research programs. Ultimately, decisions regarding health care expenditure are also a reflection of society’s willingness to pay.


Cancer Targeted Therapy Monoclonal antibodies Personalized Cancer Therapy Immunotherapy Health Economics Cost-effectiveness Analysis Cost-utility Analysis Health Technology Assessments Pricing Quality-Adjusted-Life-Year Willingness to Pay Willingness to Pay

Editors and affiliations

  • Evelyn Walter
    • 1
  1. 1.Institute for Pharmaeconomic ResearchViennaAustria

About the editors

Dr. Evelyn Walter has been head (and co-founder) of the Institute of Pharmaeconomic Research (IPF) in Vienna since 2003. The IPF’s main areas include health economic evaluation, modeling, and expert advice on reimbursement decisions, pharmaceutical pricing and distribution. She first studied Mathematics at Vienna University of Technology, before switching to the Vienna University of Economic Sciences, where she completed a Master’s and a doctorate in Economics. She has authored or co-authored some 60 publications, chiefly in refereed journals, and serves as a reviewer for several health economics journals. In Austria, she initiated the “Guidelines for Health Evaluation.” She is a Member of the Scientific Advisory Board for the “System of Health Accounts” at Statistic Austria. As a member of ISPOR (the International Society of Pharmacoeconomics and outcome Research) she co-chaired the 17th and 18th Annual European Congresses. Dr. Walter is a Lecturer at the University of Applied Sciences in Burgenland, where she teaches courses on Health Economics, Health Technology Assessment and Pharma Management. 

Bibliographic information

  • Book Title Regulatory and Economic Aspects in Oncology
  • Editors Evelyn Walter
  • Series Title Recent Results in Cancer Research
  • Series Abbreviated Title Rec.Results Cancer Research
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Medicine Medicine (R0)
  • Hardcover ISBN 978-3-030-01206-9
  • eBook ISBN 978-3-030-01207-6
  • Series ISSN 0080-0015
  • Series E-ISSN 2197-6767
  • Edition Number 1
  • Number of Pages VII, 205
  • Number of Illustrations 2 b/w illustrations, 12 illustrations in colour
  • Topics Oncology
    Health Administration
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology


“The book is written at multiple levels, so that it provides very useful information about health economics for oncology and the factors that drive policy in a fashion that would be useful for training oncologists, senior nurses, physicians, administrators, and, importantly, policymakers and the medical advisors of politicians. … I recommend this book highly to medical librarians.” (Derek Raghavan, Doody's Book Reviews, August 30, 2019)