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Gold(I,III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

  • Raphael Enoque Ferraz de Paiva

Part of the Springer Theses book series (Springer Theses)

Table of contents

  1. Front Matter
    Pages i-xxxix
  2. Au(I) Complexes

    1. Front Matter
      Pages 1-1
    2. Raphael Enoque Ferraz de Paiva
      Pages 3-43
    3. Raphael Enoque Ferraz de Paiva
      Pages 45-56
    4. Raphael Enoque Ferraz de Paiva
      Pages 57-74
    5. Raphael Enoque Ferraz de Paiva
      Pages 75-90
  3. Au(III) Complexes

    1. Front Matter
      Pages 91-91
    2. Raphael Enoque Ferraz de Paiva
      Pages 93-130
    3. Raphael Enoque Ferraz de Paiva
      Pages 131-151

About this book

Introduction

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N^N and C^N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C–S coupling.


Keywords

Gold Complexes Nucleocapsid Protein NCp7 Human Trabscription Factor Protein 1 Sp1 Zinc Finger Proteins HIV-1 Nucleocapsid Travelling-Wave Ion Mobility Mass Spectrometry X-ray Absorption Spectroscopy Citotoxicity

Authors and affiliations

  • Raphael Enoque Ferraz de Paiva
    • 1
  1. 1.Institute of ChemistryUniversity of CampinasCampinasBrazil

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-030-00853-6
  • Copyright Information Springer Nature Switzerland AG 2018
  • Publisher Name Springer, Cham
  • eBook Packages Chemistry and Materials Science
  • Print ISBN 978-3-030-00852-9
  • Online ISBN 978-3-030-00853-6
  • Series Print ISSN 2190-5053
  • Series Online ISSN 2190-5061
  • Buy this book on publisher's site
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