© 2019

Chagas Disease

A Clinical Approach

  • Jaime Marcelo Altcheh
  • Hector Freilij

Part of the Birkhäuser Advances in Infectious Diseases book series (BAID)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Overview

    1. Front Matter
      Pages 1-1
    2. Héctor Freilij
      Pages 3-22
  3. The Agent

    1. Front Matter
      Pages 23-23
    2. Catalina D. Alba Soto, Stella Maris González Cappa
      Pages 25-59
    3. Gonzalo R. Acevedo, Magali C. Girard, Karina A. Gómez
      Pages 61-88
  4. Epidemiology

    1. Front Matter
      Pages 89-89
    2. Roberto Chuit, Roberto Meiss, Roberto Salvatella
      Pages 91-109
    3. Julio Alonso-Padilla, María Jesús Pinazo, Joaquim Gascón
      Pages 111-123
    4. Melissa S. Nolan, Kyndall Dye-Braumuller, Eva Clark
      Pages 125-138
  5. Diagnosis

    1. Front Matter
      Pages 139-139
    2. Alejandro O. Luquetti, Alejandro G. Schijman
      Pages 141-158
  6. Clinical Aspects

    1. Front Matter
      Pages 159-159
    2. Guillermo Moscatelli, Samanta Moroni
      Pages 161-178
    3. Jaime Marcelo Altcheh
      Pages 179-198
    4. Ênio Chaves de Oliveira, Alexandre Barcelos Morais da Silveira, Alejandro O. Luquetti
      Pages 243-264
    5. Adelina R. Riarte, Marisa L. Fernandez, Claudia Salgueira, Javier Altclas
      Pages 265-296
  7. Treatment

    1. Front Matter
      Pages 297-297

About this book


Chagas disease is a potentially life threatening condition that was historically mainly endemic to Latin America. Over the last decade, however, the disease has spread to and is increasingly prevalent in other continents such as North America and Europe, with an estimated 7 million people infected worldwide. It is primarily transmitted by insect vectors that carry the parasite Trypanosoma cruzi, the disease agent. In areas where there is vector control and in non-endemic countries, it is mainly transmitted via congenital infection. Cardiac and gastrointestinal complications are common in untreated individuals.This book offers a comprehensive overview of Chagas disease, including its vectorial and congenital transmission, and molecular diagnosis, which is essential for screening, and developing and providing timely, effective anti-trypanosomal treatment. Written by experts working with infected patients on a daily basis, it discusses the pathogenesis of congenital, cardiac, gastrointestinal and oral Chagas disease, as well as its treatment and the pharmacological aspects of drug development in this area.

The chapter, ‘Chagas Disease Treatment Efficacy Biomarkers: Myths and Realities’ is available open access under a Creative Commons Attribution 4.0 International License via


Chagas Trypanosoma cruzi Molecular diagnosis Epidemiology Treatment Congenital infection

Editors and affiliations

  • Jaime Marcelo Altcheh
    • 1
  • Hector Freilij
    • 2
  1. 1.Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños “Ricardo Gutiérrez”Buenos AiresArgentina
  2. 2.Servicio de Parasitología y Enfermedad de Chagas, Hospital de Niños “Ricardo Gutiérrez”Buenos AiresArgentina

About the editors

Dr. Jaime Marcelo Altcheh is head of the Parasitology Service and independent researcher at Ricardo Gutierrez Children’s hospital in Buenos Aires, Argentina. 

Hector Freilij is a medical consultant at the same institution. Both are experts for tropical and especially trypanosomal diseases and have extensive worldwide collaborations and publications in international journals.

Bibliographic information

  • Book Title Chagas Disease
  • Book Subtitle A Clinical Approach
  • Editors Jaime Marcelo Altcheh
    Hector Freilij
  • Series Title Birkhäuser Advances in Infectious Diseases
  • Series Abbreviated Title Infect.Diseases
  • DOI
  • Copyright Information Springer Nature Switzerland AG 2019
  • Publisher Name Springer, Cham
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-3-030-00053-0
  • eBook ISBN 978-3-030-00054-7
  • Series ISSN 2504-3811
  • Series E-ISSN 2504-3838
  • Edition Number 1
  • Number of Pages XII, 356
  • Number of Illustrations 14 b/w illustrations, 34 illustrations in colour
  • Topics Molecular Medicine
    Infectious Diseases
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals