© 2015

Technical Aspects of Focal Therapy in Localized Prostate Cancer

  • Eric Barret
  • Matthieu Durand

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Franck Bladou
    Pages 1-8
  3. Ian A. Donaldson, Mark Emberton, Alex Freeman, Hashim U. Ahmed
    Pages 9-17
  4. John G. Mancini, Thomas J. Polascik
    Pages 19-28
  5. Alexandre Ingels, Willemien Van den Bos, Jean J. M. C. H. de la Rosette
    Pages 29-37
  6. Osamu Ukimura, Toru Matsugasumi
    Pages 39-53
  7. Petr Macek
    Pages 65-70
  8. Petr Macek
    Pages 71-79
  9. Olivier Rouvière, Thomas Sanzalone
    Pages 81-99
  10. Arjun Sivaraman, Rafael Sanchez-Salas
    Pages 101-114
  11. Matthieu Durand, Zeinab Mahate, Victoria Wijeratne
    Pages 115-135
  12. Sebastien Crouzet, Olivier Rouvière, Cyril Lafond, Jean-Yves Chapelon, Albert Gelet
    Pages 137-151
  13. Jean-Marc Cosset, Noelle Pierrat
    Pages 153-162
  14. Ashley J. Ridout, Mark Emberton, Caroline M. Moore
    Pages 163-178
  15. Nacim Betrouni, Pierre Colin
    Pages 179-190
  16. Y. Ahallal, Eric Barret
    Pages 191-198
  17. Lukman Hakim, Lorenzo Tosco, Wahjoe Djatisoesanto, Thomas Van den Broeck, Willemien van den Bos, Maarten Albersen et al.
    Pages 199-208
  18. Adil Ouzzane, Pierre Colin, Nacim Betrouni, Arnauld Villers
    Pages 209-214
  19. Rajan Ramanathan, J. Stephen Jones
    Pages 215-233

About this book


Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy.

These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity.

As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure.

Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.


Ablative therapy Focal therapy Localized prostate cancer Prostate biopsy Prostate imaging

Editors and affiliations

  • Eric Barret
    • 1
  • Matthieu Durand
    • 2
  1. 1.Department of UrologyInstitut Montsouris, Paris-Descartes UniversityParisFrance
  2. 2.Department of UrologyHôpital Pasteur 2 – Centre Hospitalier Universitaire de NiceAntipolisFrance

About the editors

Dr Eric Barret is a well-known urologist at Montsouris Institut in Paris, France and Dr Matthieu Durand is an urologist at Nice University hospital in France and specialist in cryotherapy. Prof. Guy Vallancien (Institut Montsouris, Paris, France) will write the Foreword. He is head of urology department at Montsouris Institut, Professor at Paris Descartes University, President of the European School of Surgery and Member of the Executive Committee of the French Urological Association.

International leaders in urology contribute to the book: Frank Bladdou (Mc Gill University, Montreal, Quebec), Mark Emberton (UCL, London, UK), Vladimir Mouraviev (University of Cincinnati, Cincinnati, USA), Jean DelaRosette (AMC, Amsterdam, The Netherlands), Raphaelle Renard-Penna (Pitié-Salpêtrière, Paris, France), R. Renard-Penna (Pitié-Salpêtrière, Paris, France), Hedvig Hricak (MSKCC, NYC, USA), Petr Macek (University Hospital, Pragua, Czech Republic), Albert Gelet (University Hospital, Lyon, France) Jean Marc Cosset (Institut Curie, Paris, France), Hashim Ahmed (UCL, London, UK), Scott Eggener (University of Chicago Medicine, USA), Michael J Zelesky (MSKCC, NYC, USA), Duke Bahn (PIOA, Ventura, USA), Arnaud Villers (University Hospital, Lille, France), Shahrokh Shariat (Weill Cornell Medical Center, NYC, USA), John Trachtenberg (Princess Margaret Hospital, Toronto, Canada), Laurence Klotz (Sunnybrook Health Sciences Centre, Toronto, Canada).

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology


“Recognized experts in the field describe the potential clinical impact of an emerging technology for the treatment of prostate cancer, focal therapy. … This is a very good reference for those who are contemplating including focal therapy for prostate cancer into their treatment paradigm and need a review of the contemporary issues.” (Costas D. Lallas, Doody's Book Reviews, May, 2015)