Handbook of HER2-targeted agents in breast cancer

  • Ricardo H Alvarez
  • Javier Cortés
  • Leticia De Mattos-Arruda
  • Mary Falzon
  • Angelica Fasolo
  • Michael Gandy
  • Luca Gianni
  • Nadia Harbeck
  • Martine Piccart
  • Stefania Zambelli
  • Dimitrios Zardavas

Table of contents

  1. Front Matter
    Pages I-XI
  2. Angelica Fasolo, Stefania Zambelli, Luca Gianni
    Pages 1-12
  3. Mary Falzon, Michael Gandy
    Pages 13-24
  4. Leticia De Mattos-Arruda, Javier Cortés
    Pages 43-60
  5. Dimitrios Zardavas, Martine Piccart
    Pages 75-96

About this book


​Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women worldwide, accounting for nearly a quarter of the total new cancer cases each year.  Of these cases, approximately  15–25% overexpress HER2, a transmembrane RTK kinase that is associated with aggressive tumor growth and poor outcomes.  However, in the past decade, survival rates of patients with HER-positive breast cancer have significantly improved due to increased screening, HER2 testing, and breakthrough HER2-targeted drug therapies. Handbook of HER2-Targeted Agents in Breast Cancer  provides oncologists, primary care physicians, trainees and other healthcare providers with a concise, accessible, and up-to-date survey of the field, including a review of our current understanding of the biology of the HER2 pathway and the rationale for targeting it in early-stage and advanced breast cancer, an overview of HER2-testing, and evidence-based discussions of available HER2-targeted regimens in the adjuvant and metastatic settings.


Biomarkers Breast Cancer Cancer HER2 Oncology

Authors and affiliations

  • Ricardo H Alvarez
    • 1
  • Javier Cortés
    • 2
  • Leticia De Mattos-Arruda
    • 3
  • Mary Falzon
    • 4
  • Angelica Fasolo
    • 5
  • Michael Gandy
    • 6
  • Luca Gianni
    • 7
  • Nadia Harbeck
    • 8
  • Martine Piccart
    • 9
  • Stefania Zambelli
    • 10
  • Dimitrios Zardavas
    • 11
  1. 1.Cancer CenterUniversity of Texas MD AndersonHoustonUSA
  2. 2.Vall d’Hebron Institute of OncologyBarcelonaSpain
  3. 3.Vall d’Hebron Institute of OncologyBarcelonaSpain
  4. 4.University College London HospitalLondonUnited Kingdom
  5. 5.San Raffaele Scientific InstituteMilanItaly
  6. 6.University College LondonLondonUnited Kingdom
  7. 7.San Raffaele Scientific InstituteMilanItaly
  8. 8.Breast CenterUniversity of MunichMunichGermany
  9. 9.Universite Libre de Bruxelles Insitut Jules BordetCityBelgium
  10. 10.San Raffaele Scientific InstituteMilanItaly
  11. 11.Université Libre de Bruxelles Institut Jules BordetBrusselsBelgium

Bibliographic information

  • DOI
  • Copyright Information Springer Healthcare 2013
  • Publisher Name Springer Healthcare, Tarporley
  • eBook Packages Medicine
  • Print ISBN 978-1-907673-93-1
  • Online ISBN 978-1-907673-94-8
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology