© 2011

Brain Protection in Cardiac Surgery

Volume 1

  • Robert S. Bonser
  • Domenico Pagano
  • Axel Haverich


  • Cardiac surgery textbooks are large, cumbersome and do not keep up with the pace of developments. Smaller more updateable monographs are the future for effective dissemination of information

  • Complete and thorough review of the management of cardiac surgery and the effects on the brain and brain circulation

  • Increased knowledge will assist the surgeon to choose the best procedure or combination of procedures in each case to ensure that risks do not outweigh benefits


Table of contents

  1. Front Matter
    Pages i-xv
  2. Michael A. Borger, George Djaiani, Robert A. Baker
    Pages 11-18
  3. Guy M. McKhann, Rebecca F. Gottesman, Maura A. Grega, Willam A. Baumgartner, Ola A. Selnes
    Pages 19-28
  4. Basel Ramlawi, Frank W. Sellke
    Pages 45-55
  5. Sunil K. Bhudia, David A. Stump, Timothy J. Jones
    Pages 73-81
  6. Joseph E. Arrowsmith, Maruthi S. S. R. Ganugapenta
    Pages 83-111
  7. John M. Murkin, Miguel F. Arango, Alain Deschamps, André Y. Denault
    Pages 113-129
  8. George Djaiani, Harish Ramakrishna, Alina M. Grigore
    Pages 141-157
  9. Aaron M. Ranasinghe, Timothy J. Jones
    Pages 159-175
  10. Deborah K. Harrington, Vamsidhar B. Dronavalli, Robert S. Bonser
    Pages 177-189
  11. Min Lou, Magdy Selim
    Pages 229-237

About this book


Brain injury remains one of the most dreaded complications of cardiac surgery. The range of injury is broad; while a stroke may be easily defined and diagnosed, more subtle injuries most definitely occur. There remains debate as to how these are diagnosed and there is a lack of standard definitions allowing inter-study comparison. If we are to have confidence in strategies that may reduce brain injury, we need to have confidence in the end-points used to define that injury. We need to better understand the phenomena associated with neuropsychometric testing; we need to fully elucidate the relationship between structural brain injury, embolism counting, and surrogate biomarkers; and we need an improved understanding of the clinical significance of abnormalities detected on postoperative magnetic resonance imaging. Brain Protection in Cardiac Surgery presents a detailed background of studies of neurological morbidity and neuroprotection from a range of experts in the field of neuroprotection, providing a detailed reference for clinicians in the field. The Editors have detailed connections between the different strands of injury — be it the pathology, the imaging, the clinical and cognitive examination, potential biomarkers — and have then provided summary reports of treatment strategies that may reduce such injury. As we look to the future, the design of studies attempting to reduce such injury becomes increasingly important and this book provides the fundamental background information to fuel interest, initiate novel prevention and therapeutic strategies, and inform the investigator how to develop and design their research study.

Editors and affiliations

  • Robert S. Bonser
    • 1
  • Domenico Pagano
    • 2
  • Axel Haverich
    • 3
  1. 1.Dept. Cardiothoracic SurgeonQueen Elizabeth HospitalBirminghamUnited Kingdom
  2. 2.Cardiothoracic SurgeryBirminghamUnited Kingdom
  3. 3.Klinik für Herz-, Thorax-,, Transplantations- und GefäßchirurgieMedizinische Hochschule Hannover (MHH)HannoverGermany

Bibliographic information

Industry Sectors
Health & Hospitals
Surgery & Anesthesiology


From the reviews:

“This book addresses the current understanding of the neurocognitive issues associated with the surgery. … is directed at healthcare professionals specializing in cardiac surgery - practicing surgeons and anesthesiologists, residents and fellows, intensive care physicians, neurologists and neurointensivists, researchers and other practitioners. … Select tables, graphs, illustrations, and imaging studies support the information. … a unique synopsis of the state of knowledge on this subject. It is an invaluable educational resource for a wide range of professionals whose careers are related to cardiac surgery.”­­­ (Zdravka Zafirova, Doody’s Review Service, December, 2011)