© 2008

Protein-protein Interactions and Networks

Identification, Computer Analysis, and Prediction

  • Anna Panchenko
  • Teresa Przytycka

Part of the Computational Biology book series (COBO, volume 9)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Ozlem Keskin, Attila Gursoy, Ruth Nussinov
    Pages 53-65
  3. Alfonso Valencia, Florencio Pazos
    Pages 67-81
  4. Frank Alber, Brian T. Chait, Michael P. Rout, Andrej Sali
    Pages 99-114
  5. Nir Yosef, Eytan Ruppin, Roded Sharan
    Pages 163-185
  6. Back Matter
    Pages 187-191

About this book


The biological interactions of living organisms, and protein-protein interactions in particular, are astonishingly diverse and present numerous challenges to modern biomolecular research because of their complexity. Analysis of patterns and principles governing these interactions has prompted a rapid development of computational methods to identify protein interaction partners and to understand the roles of individual components of protein interaction networks in cell functions.

This book integrates different approaches from bioinformatics, biochemistry, computational analysis and systems biology to offer the reader a comprehensive global view of the diverse data on protein-protein interactions and protein interaction networks. It brings together the descriptions of experimental techniques and expounds on different computational algorithms for protein network analysis and prediction of protein and domain interactions, with each chapter containing a description of the problem, a review of methods and algorithms, a list of resources and current conclusions.


• Reviews experimental techniques for identification of protein interactions

• Discusses protein interaction databases and methods of integrating data from diverse sources

• Describes computational methods to predict protein and domain interaction partners

• Explores the properties of interaction interfaces and highlights approaches to model the assembly of protein complexes

• Examines the topological and dynamical properties of protein interaction networks and presents the tools for comparative analysis of these networks

Written by leading experts, Protein-protein Interactions and Networks provides a broad, thorough and multidisciplinary coverage of this field. It will be invaluable to researchers from academia and the bioinformatics industry, as well as an excellent auxiliary text for graduate students studying the topic.


Homology modelling Network evolution Protein complex Protein function prediction Protein interaction prediction Protein interactions Protein networks Systems biology algorithms bioinformatics biology databases protein complexes

Editors and affiliations

  • Anna Panchenko
    • 1
  • Teresa Przytycka
    • 1
  1. 1.National Institutes of HealthBethesdaUSA

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From the reviews:

"This book consists of nine papers, written by diverse authors, each of which discusses specific problems in the area of protein-protein interactions, and different approaches to solving these problems. … offers a high-level overview of computational methods for predicting protein interactions. … This book is geared more toward biologist … ." (D. Bollman, ACM Computing Reviews, January, 2009)