Molecular Diagnostics for Melanoma

Methods and Protocols

  • Magdalena Thurin
  • Francesco M. Marincola

Part of the Methods in Molecular Biology book series (MIMB, volume 1102)

Table of contents

  1. Front Matter
    Pages i-xxiii
  2. Clinical Challenges and Current Status of Treatment of Melanoma

  3. Biomarkers for Prediction of Response and Resistance to Treatment

    1. Front Matter
      Pages 43-43
    2. Diwakar Davar, Ahmad A. Tarhini, Helen Gogas, John M. Kirkwood
      Pages 45-69
    3. Lisa H. Butterfield, Mary Jo Buffo
      Pages 71-82
    4. Michael A. Postow, Jianda Yuan, Shigehisa Kitano, Alexander M. Lesokhin, Jedd D. Wolchok
      Pages 83-95
    5. Ester Simeone, Antonio M. Grimaldi, Paolo A. Ascierto
      Pages 97-115
    6. David J. Panka, James W. Mier, Ryan J. Sullivan
      Pages 117-136
    7. Richard D. Carvajal, Omid Hamid, Cristina R. Antonescu
      Pages 137-162
  4. Biomarkers for Classification, Diagnosis, and Prognosis

    1. Front Matter
      Pages 175-175
    2. Danielle Levine, David E. Fisher
      Pages 177-197
    3. Jeffrey P. North, Swapna S. Vemula, Boris C. Bastian
      Pages 199-226
    4. Bonnie E. Gould Rothberg, David L. Rimm
      Pages 227-258
    5. Mehdi Nosrati, Mohammed Kashani-Sabet
      Pages 259-273
    6. Xiaowei Xu, Phyllis A. Gimotty, DuPont Guerry, Giorgos Karakousis, David E. Elder
      Pages 275-286
    7. Tobias Schatton, Richard A. Scolyer, John F. Thompson, Martin C. Mihm Jr.
      Pages 287-324
    8. David E. Elder
      Pages 325-351
    9. Lisa Villabona, Emilia Andersson, Maddalena Marchesi, Giuseppe V. Masucci
      Pages 353-366
    10. Alexander Marzuka-Alcalá, Michele Jacobs Gabree, Hensin Tsao
      Pages 381-393
  5. Uveal Melanoma

  6. Emerging Markers/Targets in Melanoma

    1. Front Matter
      Pages 459-459
    2. Christopher Lau, Keith J. Killian, Yardena Samuels, Udo Rudloff
      Pages 461-480
    3. Luca Sigalotti, Elisabetta Fratta, Giulia Parisi, Sandra Coral, Michele Maio
      Pages 481-499
    4. Ana Slipicevic, Rajasekharan Somasundaram, Katrin Sproesser, Meenhard Herlyn
      Pages 501-512
    5. Eiji Kiyohara, Keisuke Hata, Stella Lam, Dave S. B. Hoon
      Pages 513-522
    6. Yangyang Wang, Francesco Sabbatino, Xinhui Wang, Soldano Ferrone
      Pages 523-535
    7. Khun Visith Keu, Andrei H. Iagaru
      Pages 553-580
  7. Emerging Technologies for Marker Validation

    1. Front Matter
      Pages 581-581
    2. Elena Castellanos-Rizaldos, Coren A. Milbury, Minakshi Guha, G. Mike Makrigiorgos
      Pages 623-639
    3. John F. Quackenbush, Pamela B. Cassidy, Lawrence M. Pfeffer, Kenneth M. Boucher, Jason E. Hawkes, Susan R. Pfeffer et al.
      Pages 641-653
    4. Ryan M. Weight, John A. Viator
      Pages 655-663
  8. Marker Validation Requirements for Clinical Applicability

    1. Front Matter
      Pages 665-665
    2. Jonathan L. Curry, Michael A. Davies, Tiffany L. Calderone, Katherine Nathanson, Victor G. Prieto, Jeffrey E. Gershenwald
      Pages 679-695
  9. Back Matter
    Pages 697-712

About this book


In Molecular Diagnostics for Melanoma: Methods and Protocols, expert researchers and clinicians in the field of melanoma provide updated information on biomarkers and assays for diagnosis, prognosis, and assays predicting response to treatment for routine testing. The focus of the volume is on biomarkers with established clinical validity rather than those on early discovery stage.  With additional in-depth discussion of the molecular biology and pathology of melanoma, treatment options in adjuvant and metastatic setting, and implications of biomarker testing for clinical management of melanoma patients.


Written in the highly successful Methods in Molecular Biology series format, chapters include extensive introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.


Comprehensive and practical, Molecular Diagnostics for Melanoma: Methods and Protocols seeks to provide both clinicians and scientists with technical information and extensive background information on the wide ranging approaches available in the field of diagnostics of melanoma.


biomarkers emerging biomarkers genetic alterations markers’ detection melanoma new drugs treatment for routine testing

Editors and affiliations

  • Magdalena Thurin
    • 1
  • Francesco M. Marincola
    • 2
  1. 1.Cancer Diagnosis ProgramNational Cancer Institute, National Institutes of HealthBethesdaUSA
  2. 2.Sidra Medical and Research Center,Qatar FoundationDohaQatar

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, New York 2014
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-726-6
  • Online ISBN 978-1-62703-727-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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