Table of contents

  1. Front Matter
    Pages i-x
  2. Association of Transmembrane Helices

  3. Interactions with the Lipid Bilayer

  4. NMR Methods

    1. Front Matter
      Pages 143-143
    2. Yong Yao, Yi Ding, Ye Tian, Stanley J. Opella, Francesca M. Marassi
      Pages 145-158
    3. Fernando Porcelli, Ayyalusamy Ramamoorthy, George Barany, Gianluigi Veglia
      Pages 159-180
  5. Engineering Approaches

    1. Front Matter
      Pages 181-181
    2. Vikas Nanda, Daniel Hsieh, Alexander Davis
      Pages 183-196
    3. Arianna Rath, Charles M. Deber
      Pages 197-210
    4. Vijay M. Krishnamurthy, Krishna Kumar
      Pages 227-243
  6. Back Matter
    Pages 245-246

About this book


Focusing on model systems for the study of structure, folding, and association in the membrane, Membrane Proteins: Folding, Association, and Design presents an overview of methods that can be applied to these intricate systems. The volume is divided into four detailed sections, covering association of transmembrane helices, interactions with the lipid bilayer, NMR methods, as well as a variety of engineering approaches.  Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Authoritative and practical, Membrane Proteins: Folding, Association, and Design serves as an ideal guide for researchers reaching for the tantalizing possibility of designing novel membrane proteins with tailored functionality.


Functional artificial proteins Lipid bilayer NMR methods Protein engineering Protein folding Protein-protein interactions Transmembrane peptides

Editors and affiliations

  • Giovanna Ghirlanda
    • 1
  • Alessandro Senes
    • 2
  1. 1.Dept. of Chemistry and BiochemistryArizona State UniversityTempeUSA
  2. 2.Department of BiochemistryUniversity of Wisconsin, MadisonMadisonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-582-8
  • Online ISBN 978-1-62703-583-5
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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