Phosphatase Modulators

  • José Luis Millán

Part of the Methods in Molecular Biology book series (MIMB, volume 1053)

Table of contents

  1. Front Matter
    Pages i-x
  2. René Buchet, José Luis Millán, David Magne
    Pages 27-51
  3. Peter Teriete, Anthony B. Pinkerton, Nicholas D. P. Cosford
    Pages 85-101
  4. René Buchet, Slawomir Pikula, David Magne, Saïda Mebarek
    Pages 115-124
  5. Ekaterina V. Bobkova, Tina Kiffer-Moreira, Eduard A. Sergienko
    Pages 135-144
  6. Chen-Ting Ma, Eduard A. Sergienko
    Pages 145-154
  7. César L. Araujo, Pirkko T. Vihko
    Pages 155-166
  8. Annakaisa M. Herrala, Ileana B. Quintero, Pirkko T. Vihko
    Pages 167-178
  9. Lutz Tautz, David A. Critton, Stefan Grotegut
    Pages 179-221
  10. Souad Rahmouni, Laurence Delacroix, Wallace H. Liu, Lutz Tautz
    Pages 241-270
  11. Shannah Boens, Kathelijne Szekér, Aleyde Van Eynde, Mathieu Bollen
    Pages 271-281
  12. Caroline Lambrecht, Dorien Haesen, Ward Sents, Elitsa Ivanova, Veerle Janssens
    Pages 283-305
  13. Back Matter
    Pages 307-315

About this book


Driving further the research on mammalian alkaline phosphatase structure and function, Phosphatase Modulators collects expert contributions into one “how to” manual for basic scientists interested in initiating a drug discovery effort. While this book contains the traditional method chapters and some typical reviews on the structure and known functions of phosphatases, other contributions are meant to discuss approaches and alternatives useful in making “go/no-go” decisions in high throughput screening (HTS) and lead optimization campaigns. Many chapters focus on tissue-nonspecific alkaline phosphatase (TNAP) as well as protein phosphatases.  Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detail and key implementation advice that promotes reproducible results.


Step-by-step and practical, Phosphatase Modulators offers a path to understanding many of the facets and complexities associated with undertaking a drug discovery effort and will serve as a roadmap to initiating those efforts.


Drug discovery Medicinal chemistry Pharmaceuticals Probe development TNAP Tissue-nonspecific alkaline phosphatase

Editors and affiliations

  • José Luis Millán
    • 1
  1. 1.Sanford Children's Health Research Ctr.Sanford-Burnham Medical Research Inst.La JollaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-561-3
  • Online ISBN 978-1-62703-562-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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