Multidisciplinary Tools for Investigating Synaptic Plasticity

  • Peter Nguyen

Part of the Neuromethods book series (NM, volume 81)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Biochemical and Genetic Strategies for Probing Synaptic Plasticity and Behavior

    1. Front Matter
      Pages 1-1
    2. Jane Beil, Isabelle M. Mansuy, Thorsten Buch
      Pages 3-41
    3. Daniel B. Weatherill, Tyler W. Dunn, Patrick K. McCamphill, Wayne S. Sossin
      Pages 61-91
    4. Charles A. Hoeffer, Emanuela Santini, Eric Klann
      Pages 93-124
  3. Synaptic Development and Neurogenesis

    1. Front Matter
      Pages 125-125
    2. Declan W. Ali, Marcus E. Cunningham, Birbickram Roy
      Pages 127-139
    3. Shira Rosenzweig, J. Martin Wojtowicz
      Pages 141-155
  4. Electrophysiological and Optical Interrogation of Synaptic Physiology in Brain Slices and Dissociated Cell Preparations

  5. Back Matter
    Pages 269-274

About this book


Investigations involving incisive mechanistic dissection of various types of synaptic plasticity have revealed that it plays key roles in neural development, sensory information processing, cortical remapping following brain injury, perception, and behavioral learning and memory. Disruptions of synaptic plasticity may underlie neurological and behavioral disorders such as Alzheimer disease, Fragile-X syndrome,  autism, and drug addiction. Multidisciplinary Tools for Investigating Synaptic Plasticity, therefore, assembles expert contributions that highlight techniques and strategies used in probing the cellular and molecular mechanisms of synaptic plasticity in the nervous systems of vertebrate and invertebrate species. Divided into three sections, this meticulous volume describes biochemical and genetic strategies for studying synaptic plasticity, behavior, neural development, and synaptogenesis, and also includes cellular electrophysiological and optical methods for interrogating a diverse array of mechanistic issues. As part of the Neuromethods series, this book contains the kind of detail and key implementation advice that maximizes successful results.


Authoritative and invaluable, Multidisciplinary Tools for Investigating Synaptic Plasticity serves as an ideal primer for introducing researchers to specific techniques that will enhance their success at addressing novel questions in synaptic plasticity at the lab bench.


Behavior of synapses Biochemical and genetic strategies Brain slice preparations Cellular electrophysiological methods Neural development Optical techniques Synaptic plasticity Synaptogenesis

Editors and affiliations

  • Peter Nguyen
    • 1
  1. 1.School of Medicine, Department of PhysiologyUniversity of AlbertaEdmontonCanada

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-516-3
  • Online ISBN 978-1-62703-517-0
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site
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