Methods and Protocols

  • Paul Monagle

Part of the Methods in Molecular Biology book series (MIMB, volume 992)

Table of contents

  1. Front Matter
    Pages i-xii
  2. The Haemostatic System

    1. Front Matter
      Pages 1-1
    2. Anthony K. C. Chan, Nethnapha Paredes
      Pages 3-12
    3. Matthew D. Linden
      Pages 13-30
    4. Nethnapha Paredes, Anthony K. C. Chan
      Pages 31-46
  3. General Principles of Haemostatic Testing

    1. Front Matter
      Pages 47-47
    2. Linda J. Stang, Lesley G. Mitchell
      Pages 49-71
    3. Gemma Crighton
      Pages 73-83
    4. Oliver Speer, Markus Schmugge, Claudia Metzger, Manuela Albisetti
      Pages 85-96
    5. Karen Moffat, Anne Raby, Mark Crowther
      Pages 97-108
  4. Examples of Global Tests of Haemostasis

    1. Front Matter
      Pages 109-109
    2. Vera Ignjatovic
      Pages 111-120
    3. Vera Ignjatovic
      Pages 121-129
    4. Vera Ignjatovic
      Pages 131-138
    5. Leslie R. Berry, Anthony K. C. Chan
      Pages 139-154
    6. Stephen Horton, Simon Augustin
      Pages 155-167
  5. Examples of Tests for Bleeding Disorders

    1. Front Matter
      Pages 169-169
    2. Stephen Opat, Jenny Butler, Erica Malan, Elizabeth Duncan, Huyen A. M. Tran
      Pages 171-180
    3. Linda J. Stang, Lesley G. Mitchell
      Pages 181-192
    4. Sylvain Salignac, Véronique Latger-Cannard, Nicole Schlegel, Thomas Pierre Lecompte
      Pages 193-205
    5. Véronique Latger-Cannard, Odile Fenneteau, Sylvain Salignac, Thomas Pierre Lecompte, Nicole Schlegel
      Pages 207-225
    6. Juan Pablo Frontroth
      Pages 227-240
    7. Matthew D. Linden
      Pages 241-262
  6. Examples of Specific Assays Related to Anticoagulant Activity

    1. Front Matter
      Pages 263-263
    2. Fiona Newall
      Pages 265-272
    3. Hratsch Karapetian
      Pages 273-277
    4. Fiona Newall
      Pages 279-287
    5. Andreas Greinacher, Birgitt Fürll, Sixten Selleng
      Pages 301-318
  7. Examples of Tests for Inhibitors of Coagulation

    1. Front Matter
      Pages 319-319
    2. Elizabeth Duncan, Margaret Collecutt, Alison Street
      Pages 321-333
    3. Kottayam Radhakrishnan
      Pages 335-339
    4. Kottayam Radhakrishnan
      Pages 341-348
    5. Kottayam Radhakrishnan
      Pages 349-351
  8. Examples of Tests for Increased Risk of Thrombosis

    1. Front Matter
      Pages 353-353
    2. Mirta Hepner, Vasiliki Karlaftis
      Pages 355-364
    3. Mirta Hepner, Vasiliki Karlaftis
      Pages 365-372
    4. Mirta Hepner, Vasiliki Karlaftis
      Pages 373-381
    5. Anne Raby, Karen Moffat, Mark Crowther
      Pages 387-405
    6. Claus Langer, Bertram Tambyrayah, Ulrike Nowak-Göttl
      Pages 407-412
  9. Examples of Measures of Fibrinolysis

    1. Front Matter
      Pages 413-413
  10. Back Matter
    Pages 429-431

About this book


The haemostatic system is one the most important physiological systems for maintaining health and well being, and thus the investigation of the haemostatic system remains a research priority. Disturbances of the haemostatic system in the broader sense, such as heart disease and strokes, arguably constitute the single greatest contribution to non-infectious mortality in the world today. Therefore, understanding the laboratory methods to assess the haemostatic system is vital for the practice of complex clinical medicine. In Haemostasis: Methods and Protocols, experts in the field address the major components of the haemostatic system, general principles of haemostatic testing, and techniques used to assess various aspects of the haemostatic system, grouped according to their functional indications. Written in the successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.


Authoritative and easily accessible, Haemostasis: Methods and Protocols provides an ideal guide to scientists of all backgrounds and serves an urgent need for further research to develop superior methods of assessing the haemostatic system in humans.


clotting time coagulation fibrinolysis haemostasis thrombosis

Editors and affiliations

  • Paul Monagle
    • 1
  1. 1.Department of PaediatricsUniversity of MelbourneParkvilleAustralia

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2013
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-62703-338-1
  • Online ISBN 978-1-62703-339-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals