Intrinsically Disordered Protein Analysis

Volume 1, Methods and Experimental Tools

  • Vladimir N. Uversky
  • A. Keith Dunker

Part of the Methods in Molecular Biology book series (MIMB, volume 895)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Assessing IDPS in the Living Cell

    1. Front Matter
      Pages 1-1
    2. Yutaka Ito, Tsutomu Mikawa, Brian O. Smith
      Pages 19-31
    3. Rossukon Thongwichian, Philipp Selenko
      Pages 33-41
    4. Beata Bekei, Honor May Rose, Michaela Herzig, Alexander Dose, Dirk Schwarzer, Philipp Selenko
      Pages 43-54
    5. Beata Bekei, Honor May Rose, Michaela Herzig, Philipp Selenko
      Pages 55-66
    6. Beata Bekei, Honor May Rose, Michaela Herzig, Heike Stephanowitz, Eberhard Krause, Philipp Selenko
      Pages 67-83
    7. Apratim Dhar, Maxim Prigozhin, Hannah Gelman, Martin Gruebele
      Pages 101-111
  3. NMR-Based Techniques

    1. Front Matter
      Pages 113-113
    2. Loïc Salmon, Malene Ringkjøbing Jensen, Pau Bernadó, Martin Blackledge
      Pages 115-125
    3. Stepan Kashtanov, Wade Borcherds, Hongwei Wu, Gary W. Daughdrill, F. Marty Ytreberg
      Pages 139-152
    4. K. Tompa, M. Bokor, P. Tompa
      Pages 167-196
    5. Candace M. Pfefferkorn, Jennifer C. Lee
      Pages 197-209
  4. Vibrational Spectroscopy

    1. Front Matter
      Pages 227-227
    2. Hailiu Yang, Johnny Habchi, Sonia Longhi, Casey H. Londergan
      Pages 245-270
    3. Reinhard Schweitzer-Stenner, Jonathan B. Soffer, Daniel Verbaro
      Pages 271-313
    4. Reinhard Schweitzer-Stenner, Jonathan B. Soffer, Siobhan Toal, Daniel Verbaro
      Pages 315-346
    5. Ginka S. Buchner, Jan Kubelka
      Pages 347-358
  5. Other Spectroscopic Techniques

    1. Front Matter
      Pages 359-359
    2. Johnny Habchi, Marlène Martinho, Antoine Gruet, Bruno Guigliarelli, Sonia Longhi, Valérie Belle
      Pages 361-386
    3. Lucía B. Chemes, Leonardo G. Alonso, María G. Noval, Gonzalo de Prat-Gay
      Pages 387-404
    4. Paolo Neyroz, Stefano Ciurli
      Pages 435-440
    5. Anna I. Sulatskaya, Olga I. Povarova, Irina M. Kuznetsova, Vladimir N. Uversky, Konstantin K. Turoverov
      Pages 441-460
    6. Sarah Schreurs, Malgorzata Kluba, Jessika Meuvis, Yves Engelborghs
      Pages 461-466
  6. Back Matter
    Pages 507-511

About this book


Over the past decade, there has been an explosive development of research of intrinsically disordered proteins (IDPs), which are also known as unfolded proteins. Structural biologists now recognize that the functional diversity provided by disordered regions complements the functional repertoire of ordered protein regions. In Intrinsically Disordered Protein Analysis :Methods and Experimental Tools, expert researchers explore the high abundance of IDPs in various organisms, their unique structural features, numerous functions, and crucial associations with different diseases. Volume 1 includes sections on assessing IDPs in the living cell,NMR based techniques, vibrational spectroscopy, and other spectroscopic techniques. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory.


Thorough and intuitive, Intrinsically Disordered Protein Analysis: Methods and Experimental Tools helps scientists further their investigations of these fascinating and dynamic molecules.


IDPs disorder functional properties globular proteins physico-chemical structural properties unfolded proteins unfoldomics

Editors and affiliations

  • Vladimir N. Uversky
    • 1
  • A. Keith Dunker
    • 2
  1. 1.Department of Molecular Medicine, College of MedicineUniversity of South FloridaTampaUSA
  2. 2.Dept. Biochemistry & Molecular Biology, Center for Computational Biology &Indiana UniversityIndianapolisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-926-6
  • Online ISBN 978-1-61779-927-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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