Developmental Toxicology

Methods and Protocols

  • Craig Harris
  • Jason M. Hansen

Part of the Methods in Molecular Biology book series (MIMB, volume 889)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Craig Harris
    Pages 1-5
  3. Jason M. Hansen
    Pages 7-13
  4. Windy A. Boyd, Marjolein V. Smith, Jonathan H. Freedman
    Pages 15-24
  5. Julieta M. Panzica-Kelly, Cindy X. Zhang, Karen Augustine-Rauch
    Pages 25-50
  6. Susan M. Smith, George R. Flentke, Ana Garic
    Pages 85-103
  7. M. Pratten, Bhavesh K. Ahir, H. Smith-Hurst, S. Memon, P. Mutch, P. Cumberland
    Pages 115-146
  8. Béatrice Kuske, Polina Y. Pulyanina, Nicole I. zur Nieden
    Pages 147-179
  9. Marianne Barrier, Kelly Chandler, Susan Jeffay, Maria Hoopes, Tom Knudsen, Sid Hunter
    Pages 181-195
  10. France-Hélène Paradis, Chunwei Huang, Barbara F. Hales
    Pages 197-213
  11. Craig Harris
    Pages 215-237
  12. Valerie A. Marshall, Edward W. Carney
    Pages 239-252
  13. Jared V. Goldstone, John J. Stegeman
    Pages 265-275
  14. Trent E. Tipple, Lynette K. Rogers
    Pages 315-324
  15. Craig Harris, Jason M. Hansen
    Pages 325-346
  16. Joshua F. Robinson, Jeroen L. A. Pennings, Aldert H. Piersma
    Pages 347-371
  17. Elena Menegola, Graziella Cappelletti, Francesca Di Renzo
    Pages 373-383
  18. Karilyn E. Sant, Muna S. Nahar, Dana C. Dolinoy
    Pages 385-406
  19. Jeffrey Ambroso, Craig Harris
    Pages 407-423
  20. Ulf J. Eriksson, Parri Wentzel
    Pages 425-436
  21. Robert E. Seegmiller, Nathan Cook, Korance Goodwin, Timothy Leishman
    Pages 451-463
  22. Back Matter
    Pages 465-471

About this book


The discipline of developmental toxicology is an integration of concepts, models, and methodologies based heavily on the superimposition of toxicology principles upon the science of developmental biology.  The science of developmental toxicology also borrows from other research areas that are concerned with regulation of cell growth, migration, differentiation and cell death, as such are central to the study of stem cells, cancer, and chronic diseases. In Developmental Toxicology: Methods and Protocols expert researchers in the field detail many of the methods which are now commonly used to study developmental toxicology highlighting the evolution of methods from classical teratology approaches to the dynamic, state-of-the-art molecular methods, systems biology, and next generation models and procedures. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.


Authoritative and practical, Developmental Toxicology: Methods and Protocols is a valuable resource to those planning experiments to investigate consequences of environmental, nutritional, or chemical effects caused during development.


antioxidant biotransformation of chemicals cell death cell growth developmental toxicology embryogenesis fetogenesis in vitro models in vivo study models migration protective pathways

Editors and affiliations

  • Craig Harris
    • 1
  • Jason M. Hansen
    • 2
  1. 1.Toxicology Program, Dept. Environmental Health SciencesUniversity of MichiganAnn ArborUSA
  2. 2., Department of PediatricsEmory UniversityAtlantaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-61779-866-5
  • Online ISBN 978-1-61779-867-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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