© 2012

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 2

  • Jun Chen
  • Xiao-Ming Xu
  • Zao C. Xu
  • John H. Zhang


  • Presents the material in a disease/disorder oriented manner for convenient reference

  • Offers both recommended, established techniques and alternative methods that have their own special utility

  • Features key tips and implementation advice to ensure successful results


Part of the Springer Protocols Handbooks book series (SPH)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. R. Anne Stetler, Miguel A. Perez-Pinzon
    Pages 1-3
  3. Global Cerebral Ischemia

  4. Focal Cerebral Ischemia

    1. Front Matter
      Pages 91-91
    2. Feng Zhang, Steven H. Graham, Jun Chen
      Pages 107-114
    3. Xiaoming Hu, Jun Chen
      Pages 139-148
    4. Feng-Yan Sun, Xiao Sun, Ji-Jiang Wang, Qiu-Wan Zhang, Yong-Quan Wang
      Pages 163-179

About this book


The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.  Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.  Volume 2 examines global cerebral ischemia, focal cerebral ischemia, and neonatal hypoxia-ischemia, as well as intensive sections covering traumatic brain injury and spinal cord injury.  Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.


Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.


Acute neurological injury Animal models Focal cerebral ischemia Global cerebral ischemia Neonatal Hypoxia-Ischemia Spinal cord injury Traumatic brain injury

Editors and affiliations

  • Jun Chen
    • 1
  • Xiao-Ming Xu
    • 2
  • Zao C. Xu
    • 3
  • John H. Zhang
    • 4
  1. 1.School of MedicineUniversity of PittsburghPittsburghUSA
  2. 2.School of Medicine, Stark Neurosciences Res. Inst.Indiana UniversityIndianapolisUSA
  3. 3.School of Medicine, Department of Anatomy & Cell BiologyIndiana UniversityIndianapolisUSA
  4. 4.School of Medicine, Dept. NeurosurgeryLoma Linda UniversityLoma LindaUSA

Bibliographic information

  • Book Title Animal Models of Acute Neurological Injuries II
  • Book Subtitle Injury and Mechanistic Assessments, Volume 2
  • Editors Jun Chen
    Xiao-Ming Xu
    Zao C. Xu
    John H. Zhang
  • Series Title Springer Protocols Handbooks
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-61779-781-1
  • Softcover ISBN 978-1-4939-6052-1
  • eBook ISBN 978-1-61779-782-8
  • Series ISSN 1949-2448
  • Series E-ISSN 1949-2456
  • Edition Number 1
  • Number of Pages XVIII, 718
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
    Animal Models
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


“This an atlas-text ‘protocols’ step by step explanation of animal cerebral ischemia, brain trauma, & spinal cord injury. … I recommend this book for ischemia and trauma students and physiology students.” (Joseph J. Grenier,, October, 2015)