© 2012

Animal Models of Acute Neurological Injuries II

Injury and Mechanistic Assessments, Volume 1

  • Jun Chen
  • Xiao-Ming Xu
  • Zao C. Xu
  • John H. Zhang


  • Presents the material in a disease/disorder oriented manner for convenient reference

  • Offers both recommended, established techniques and alternative methods that have their own special utility

  • Features key tips and implementation advice to ensure successful results


Part of the Springer Protocols Handbooks book series (SPH)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. General Morphological Assessments

    1. Front Matter
      Pages 1-1
    2. Thomas Genetta, Ling Wei, Shan Ping Yu
      Pages 13-29
    3. Rabindra P. Singh, Li Shen, Feng C. Zhou
      Pages 31-52
  3. General Physiological Assessments

    1. Front Matter
      Pages 71-71
    2. Casey Lee Hall, Osama Mohamad, Shan Ping Yu, Ling Wei
      Pages 73-91
  4. General Biochemical and Molecular Biological Assessments

    1. Front Matter
      Pages 133-133
    2. Marcel P. Van der Brug, Mar Matarin, Taura L. Barr
      Pages 135-160
    3. Anthony Kian-Fong Liou, Jun Chen
      Pages 171-186
    4. Lesley K. Harris, Raiford T. Black, Thomas M. Reeves, Linda L. Phillips
      Pages 187-201
  5. General Neurobehavioral Assessments

    1. Front Matter
      Pages 203-203
    2. Xinmin Simon Xie, Jingxi Zhang, Bende Zou, James Xie, Jidong Fang, Nurulain T. Zaveri et al.
      Pages 205-222
    3. Richard E. Hartman
      Pages 235-253

About this book


The successful previous volume on this topic provided a detailed benchwork manual for the most commonly used animal models of acute neurological injuries including cerebral ischemia, hemorrhage, vasospasm, and traumatic brain and spinal cord injuries.  Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments aims to collect chapters on assessing these disorders from cells and molecules to behavior and imaging. These comprehensive assessments are the key for understanding disease mechanisms as well as developing novel therapeutic strategies to ameliorate or even prevent damages to the nervous system.  Volume 1 examines general assessments in morphology, physiology, biochemistry and molecular biology, neurobehavior, and neuroimaging, as well as extensive sections on subarachnoid hemorrhage, cerebral vasospasm, and intracerebral hemorrhage.  Designed to provide both expert guidance and step-by-step procedures, chapters serve to increase understanding in what, why, when, where, and how a particular assessment is used.


Accessible and essential, Animal Models of Acute Neurological Injuries II: Injury and Mechanistic Assessments will be useful for trainees or beginners in their assessments of acute neurological injuries, for experienced scientists from other research fields who are interested in either switching fields or exploring new opportunities, and for established scientists within the field who wish to employ new assessments.


Acute neurological injury Animal models Cerebral vasospasm General assessments Intracerebral hemorrhage Morphological assessments Neurobehavior Neuroimaging Subarachnoid hemorrhage

Editors and affiliations

  • Jun Chen
    • 1
  • Xiao-Ming Xu
    • 2
  • Zao C. Xu
    • 3
  • John H. Zhang
    • 4
  1. 1.School of MedicineUniversity of PittsburghPittsburghUSA
  2. 2.School of Medicine, Stark Neurosciences Res. Inst.Indiana UniversityIndianapolisUSA
  3. 3.School of Medicine, Department of Anatomy & Cell BiologyIndiana UniversityIndianapolisUSA
  4. 4.School of Medicine, Dept. NeurosurgeryLoma Linda UniversityLoma LindaUSA

Bibliographic information

  • Book Title Animal Models of Acute Neurological Injuries II
  • Book Subtitle Injury and Mechanistic Assessments, Volume 1
  • Editors Jun Chen
    Xiao-Ming Xu
    Zao C. Xu
    John H. Zhang
  • Series Title Springer Protocols Handbooks
  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2012
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-61779-575-6
  • Softcover ISBN 978-1-4939-6222-8
  • eBook ISBN 978-1-61779-576-3
  • Series ISSN 1949-2448
  • Series E-ISSN 1949-2456
  • Edition Number 1
  • Number of Pages XVIII, 724
  • Number of Illustrations 42 b/w illustrations, 125 illustrations in colour
  • Topics Neurosciences
    Animal Models
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals